Sustained Immunoparalysis in Endotoxin-Tolerized Monocytic Cells
Table 1
Upon 18 h LPS tolerization (10 ng LPS/ml media or PBS as control, 106 cells/ml), methylome analysis of DNA derived from healthy human PBMC donors () was performed and KEGG pathway results are presented.
Top KEGG pathways
DE
P.DE
FDR
1
path:hsa01100
Metabolic pathways
1252
870
6,27-255
2,01-252
2
path:hsa05200
Pathways in cancer
394
316
1,20-97
1,93-95
3
path:hsa05165
Human papillomavirus infection
318
244
1,79-66
1,91-64
4
path:hsa04151
PI3K-Akt signaling pathway
339
243
9,24-59
7,39-57
5
path:hsa04010
MAPK signaling pathway
255
197
5,27-50
3,37-48
6
path:hsa05166
HTLV-I infection
252
192
1,05-49
5,63-47
7
path:hsa04360
Axon guidance
174
151
2,22-45
1,01-43
8
path:hsa04144
Endocytosis
244
186
4,18-45
1,67-43
9
path:hsa04015
Rap1 signaling pathway
210
167
1,86-44
6,61-42
10
path:hsa04014
Ras signaling pathway
226
173
2,24-43
7,15-42
11
path:hsa05169
Epstein-Barr virus infection
197
156
3,43-41
9,97-42
12
path:hsa04510
Focal adhesion
198
159
4,35-41
1,16-38
13
path:hsa05205
Proteoglycans in cancer
203
157
1,11-37
2,74-36
14
path:hsa04810
Regulation of actin cytoskeleton
211
160
8,19-37
1,87-35
15
path:hsa05202
Transcriptional misregulation in cancer
181
141
7,12-36
1,52-34
16
path:hsa05203
Viral carcinogenesis
198
149
1,27-35
2,53-34
17
path:hsa05167
Kaposi’s sarcoma-associated herpesvirus infection
186
140
2,96-35
5,58-34
18
path:hsa04022
cGMP-PKG signaling pathway
162
132
1,17-35
2,09-34
19
path:hsa05016
Huntington’s disease
186
140
1,65-34
2,79-33
20
path:hsa04141
Protein processing in endoplasmic reticulum
165
131
1,85-34
2,96-33
KEGG pathway: code from Kyoto Encyclopedia of Genes and Genomes; : number of KEGG pathway-related CpG sites contained in array; DE: number of differentially methylated CpG sites; P.DE: adjusted differential methylation value; FDR: false discovery rate.
