Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy

Figure 5

Neutralizing IL-21R in vivo inhibits IMQ-induced epidermal thickening, cutaneous MDSCs infiltration, and splenic Th17 infiltration. (a) Schematic illustration of the experimental setup. (b) The H&E staining of the back skin derived from mice injected intraperitoneally with vehicle (IMQ+vehicle) or anti-mouse IL-21R antibody (IMQ+anti-IL-21R) or untreated (Normal) (one representative mouse is presented, mice per group). Scale bars: 100 μm. Statistical analysis data is shown in (B). (c) Representative flow cytometry panels for quantification and FMO-control of cutaneous MDSCs and splenic Th17 cells of BALB/c mice ( mice per group). CD11b⁺ Gr-1⁺ cells were selected from CD45⁺ cells. Statistical analysis data is shown in (B). (d) Schematic illustration of targeting MDSCs attenuates IMQ-induced psoriasis-like skin inflammation. , , , and ; ns, not significant. One-way ANOVA with Dunnett’s post hoc test was used.

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