Research Article
Paeonol Attenuates Methotrexate-Induced Cardiac Toxicity in Rats by Inhibiting Oxidative Stress and Suppressing TLR4-Induced NF-κB Inflammatory Pathway
Figure 5
Effect of paeonol (PAE) on cardiac caspase 3 immunostaining in methotrexate- (MTX-) induced cardiac toxicity in rats. (a) Control group showing minimal expression. (b) MTX-treated group showing positive cytoplasmic and nuclear expression (arrow). (c) PAE+MTX group showing positive expression in scattered cells (arrow). (d) Semiquantitative analysis of the results. Values represent . “A” means significant difference compared to the control group and “B” means significant difference compared to the MTX-treated group, at .
(a) |
(b) |
(c) |
(d) |