Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammatory Response
SalD increased cell viability, reduced LDH release, and inhibited apoptosis and the inflammatory response induced by OGD/R injury in PC12 cells. (a) Cell viability (). (b) LDH release (). (c) The relative Bax/Bcl-2 ratio (). (d) The relative intensity of cleaved caspase-3 (). (e) The relative intensity of cleaved caspase-9 (). (f) The relative intensity of cytochrome c (). (g) The generation of TNF-α, IL-1β, and IL-6 cytokines (). (h) The transcription of TNF-α, IL-1β, and IL-6 mRNA (). Proteins were acquired from PC12 cells and assayed by the Western blot method. The intensity was normalized to β-actin. Data were expressed as .## versus the control group; and versus the OGD/R group.
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