Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammatory Response
SalD inhibited HMGB1 cytoplasmic translocation and NF-κB nuclear translocation in the cortex and hippocampus of I/R rats. (a) The relative intensity of TLR4 (). (b) The relative intensity of MyD88 (). (c) The relative intensity of TRAF6 (). (d) The relative p-NF-κB p65/NF-κB p65 ratio (). (e) The relative intensity of cytoplasmic HMGB1 (). (f) The relative intensity of nuclear HMGB1 (). Protein samples were acquired from the cortex or hippocampus region and assayed by the Western blot method. Nuclear proteins were normalized to the intensity of Lamin B1, while other proteins were normalized to the intensity of β-actin. Data were expressed as .## versus the sham operation group; and 1 versus the MCAO/R group.
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