Anti-Inflammatory Profile of Jungia sellowii Less. by Downregulation of Proinflammatory Mediators and Inhibition of NF-κB and p38 Pathways

Table 1

Effects of the crude extract (CE) of Jungia sellowii Less., its derived fractions (aqueous (AqF), butanol (BuOHF), ethyl acetate (EtOAcF)), and isolated compounds (curcuhidroquinone O-β-glucose (CUR) and Piptizol (Pip)), upon leukocyte, neutrophil, mononuclear, and protein concentrations of the exudate, in the inflammation induced by carrageenan in the mouse model of pleurisy.

Groups	Doses (mg/kg)	Leukocytes (×10^6) (% of inhibition)	Neutrophils (×10^6) (% of inhibition)	Mononuclear (×10^6) (% of inhibition)	Protein concentrations (μg/mL) (% of inhibition)
Sal	0.9%^a
Cg	1%^a
CE	25^b
	50^b	()	()		()
	100^b	()	()		()
	200^b	()	()		()
AqF	10^b				()
	25^b	()	()	1	()
	50^b	()	()		()
BuOHF	5^b
	10^b	(23.98 ± 4.81%)	(21.58 ± 4.59%)		(31.98 ± 5.79%)
	25^b	()	()		()
EtOAcF	5^b
	10^b	()	()		()
	25^b	()	()		()
CUR	1^b				()
	2.5^b	()	()	()	()
	5^b	()	()		()
Pip	0.5^b				()
	1^b	()	()		()
	2.5^b	()	()		()
	5^b	()	()		()
Dex	0.5^b	()	()		()

Crude extract (CE: 25-200 mg/kg) of Jungia sellowii Less., aqueous fraction (AqF 10-50 mg/kg), butanol fraction (BuOHF 5-25 mg/kg), ethyl acetate fraction (EtOAcF: 5-25 mg/kg), curcuhidroquinone O-β-glucose (CUR: 1-5 mg/kg), and piptizol (Pip: 0.5-5 mg/kg) administered 0.5 h before pleurisy induction by carrageenan (1%). Sal: animals treated only with sterile saline solution (NaCl, 0.9%); Cg: animals treated only with carrageenan (1%); Dex: animals pretreated with dexamethasone (0.5 mg/kg); ^aadministered by intrapleural injection (i.pl.); ^badministered by intraperitoneal route (i.p.). Each group represents the of 5 animals compared to the positive control group (Cg); ANOVA/Newman-Keuls’s test. ; .