Leptin Promoted IL-17 Production from ILC2s in Allergic Rhinitis
Comparison of serum leptin expression and the frequency of IL-17-producing ILC2s between AR and controls. Gating strategy of ILC2 and representative flow cytometry showed IL-17-producing ILC2 frequency (a, b). The protein expression of serum leptin and the frequency of IL-17-producing ILC2s by ELISA between 15 AR patients and 15 controls (c, d). The correlation between serum leptin and the frequency of IL-17-producing ILC2s in 15 AR patients (e). Compared with controls, . IL-25 (50 ng/ml), IL-33 (50 ng/ml), TSLP (50 ng/ml), and IL-2 (10 U/ml) were added for 72 hours’ stimulation. values were determined by using the Mann–Whitney test. Correlation was determined by using the Spearman rank method.
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