Luteolin Attenuates IL-1<i>β</i>-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-<i>κ</i>B and MAPK Pathways

<div>Luteolin blocked JNK phosphorylation, and the JNK inhibitor SP60012 (SP) decreased THP-1 cell adherence to IL-1<i>β</i>-stimulated ARPE-19 cells. (a) Western blots show the levels of phosphorylated JNK protein expression. (b) The fold-change in pJNK protein expression was measured relative to JNK expression. (c) ARPE-19 cells were pretreated with 10 <i>μ</i>M luteolin or JNK inhibitor (SP600125) for 1 h and then cocultured with labeled THP-1 cells. (d) The fluorescence intensity was used to quantify calcein-AM fluorescence. 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Mediators of Inflammation

fig5

Figure 5

Figure 5: Luteolin Attenuates IL-1<i>β</i>-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-<i>κ</i>B and MAPK Pathways 

Mediators of Inflammation

Luteolin Attenuates IL-1β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-κB and MAPK Pathways

Figure 5