Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: A Mini Review

Figure 1

The occurrence of IBD and its relationship with Tregs. The pathophysiology of IBD is multifactorial and not completely understood, but genetic components, dysregulated immune responses, oxidative stress, and inflammatory mediators are known to be involved. Tregs are related to the occurrence and development of IBD, and IBD can be cured or alleviated by inducing the generation of Tregs or direct administration of Tregs. Treg: regulatory T cell; TNF-α: tumor necrosis factor α; TNF-β: tumor necrosis factor β; iTregs: inducible regulatory T cells; nTregs: natural regulatory T cells; IBD: inflammatory bowel disease.