Dysregulation of Innate Lymphoid Cells in Patients with Active Rheumatoid Arthritis and Mice with Collagen-Induced Arthritis

Figure 1

ILC subsets in the peripheral blood of HCs, patients with stable RA, and patients with active RA. (a) Gating strategy for total ILCs (CD45+CD3-Lineage-CD161+CD127+), cNK cells (CD3-CD16+/CD56+), ILC1s (CD294-CD117-), ILC2s (CD294+CD117-), and ILC3s (CD294-CD117+). (b) Absolute counts of total ILCs per mL of peripheral blood. (c) Percentage of CD16+/CD56+ cNK cells among CD3- cells. (d–f) Proportions of ILC1s, ILC2s, and ILC3s among total ILCs. (g) Correlations of the total number of ILCs with DAS28-CRP (A) and with DAS28-ESR (B). (h–j) Correlations of proportions of ILC1s, ILC2s, and ILC3s in total ILCs with DAS28-CRP (A) and DAS28-ESR (B). Data are expressed as and compared using the unpaired Student’s -test. Spearman’s rank correlation coefficients and values are indicated. , , and . RA: rheumatoid arthritis; HC: healthy control; DAS28: disease activity score for 28 joints; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate. HC: ; stable RA: ; and active RA: .

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