Cholinergic Elicitation Prevents Ventricular Remodeling via Alleviations of Myocardial Mitochondrial Injury Linked to Inflammation in Ischemia-Induced Chronic Heart Failure Rats

Figure 10

A schematic diagram of the cardioprotection of cholinergic elicitation to heart failure induced by MI. During the period of postinfarction heart advance into heart failure, chronic inflammation response induced by initial proinflammatory cytokines begets a detrimental pathophysiological circle through disturbing the mitochondrial biogenesis and eventually contributes to the ventricular remodeling. Such aforementioned vicious circle may be partly interrupted by cholinergic elicitation.