Cholinergic Elicitation Prevents Ventricular Remodeling via Alleviations of Myocardial Mitochondrial Injury Linked to Inflammation in Ischemia-Induced Chronic Heart Failure Rats

Figure 8

Effects of cholinergic elicitation on myocardial mitochondrial dynamics and the activities of NF-κB and JAK2/STAT3 pathway. Western blot results and quantitative statistics for Drp1, Fis1, Mfn1, Mfn2, Opa1, α7nAChR, NF-κB, P-NF-κB, JAK2, P-JAK2, STAT3, and p-STAT3 (a–m). vs. Sham group. ^# vs. CHF group. ^$ vs. CHF+Vag group. ^& vs. CHF+PNU group. Drp1: dynamin-related protein 1; Fis1: fission, mitochondrial 1; Mfn1: mitofusin 1; Mfn2: mitofusin 2; Opa1: OPA1 mitochondrial dynamin-like GTPase; α7nAChR: α7-nicotinic acetylcholine receptor; NF-κB: nuclear factor kappa B; p-NF-KB: phosphorylated nuclear factor kappa B; JAK2: Janus kinase 2; p-JAK2: phosphorylated Janus kinase 2; STAT3: signal transducer and activator of transcription 3; p-STAT3: phosphorylated signal transducer and activator of transcription 3.

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