The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism

<div>FoxO1 and SREBP-1c inhibited each other and regulated Huh-6 cell functions. (a) RT-qPCR detected the relative expression levels of FoxO1 and SREBP-1c. (b) ChIP was performed to detect the direct interaction between the FoxO1 gene and SREBP-1c protein. (c) CCK8 assay was used to detect cell proliferation. (d) Cell migration was evaluated by scratch assay. (e) Transwell assay was performed to examine cell invasion. 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All experiments were performed 3 times.</div>

Mediators of Inflammation

fig4

Figure 4

Figure 4: The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism 