Research Article
Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis
Figure 3
TL1A promotes colon fibrosis in the DSS-induced intestinal fibrosis model. (a) Sirius red staining of collagen deposition in colon from wild type and transgenic (Tg) mice overexpressing TL1A (100x). (b) Fibrosis scores reflect fibrotic alterations of colonic sections. (c) The relative minimal (min) and maximal (max) width of submucosa in mice. (d) Hydroxyproline content. (e–g) Western blot analysis of collagen I and collagen III in colonic tissues normalized with GAPDH. (h, i) RT-PCR detection of collagen I and collagen III mRNA. Data were given as (SD). As compared to the control group: , , and .
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