IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome

Figure 6

Effects of IL-38 stimulation or blockade on 7-day survival of septic mice. Kaplan Meier survival plot of mice treated as indicated. Septic mice were given PBS (blue line) or IL-38 (1 μg per mouse), then subjected 2 h later to cecal ligation and puncture (CLP) (green line). Other animals were subjected to CLP, then immediately injected intraperitoneally with anti-IL-38 antibody (50 μg per animal), followed 24 h later by a booster dose of 50 μg (red line). vs. the CLP+PBS group. Results are shown for 25 mice per group.