Lipocalin 10 as a New Prognostic Biomarker in Sepsis-Induced Myocardial Dysfunction and Mortality: A Pilot Study

Table 1

Demographic and clinical data of the study population. Values expressed in percentages (%) indicate the proportion of patients within each cohort for each variable. Data are presented as median with interquartile ranges (IQR) where specified. SIMD: sepsis-induced myocardial dysfunction; BMI: body mass index; BP: blood pressure; CRP: c-reactive protein; PCT: procalcitonin; APACHE: Acute Physiology: Age and Chronic Health Evaluation; SOFA: Sequential Organ Failure Assessment; NT-proBNP: N-terminal pro-b-type natriuretic peptide; hs-TnI: high-sensitivity troponin I; CK-MB: creatine kinase-MB; Lcn10: lipocalin 10. .

Variables	Non-SIMD ()	SIMD ()	value
Age (y), median (IQR)	62.5 (55.3-68.8)	58.0 (53.0-67.0)	0.189
Gender, male, (%)	20 (50%)	21 (60%)	0.386
BMI (kg/m^2), median (IQR)	22.0 (20.0-25.75)	20.0 (19.0-22.0)	0.071
Hospital length of stay (days), median (IQR)	7 (5-12)	7 (6-11)	0.905
Death before day 28, (%)	4 (10%)	11 (31.4%)	0.021
Systolic BP (mmHg), median (IQR)	97 (86-119)	90 (80-97)	0.046
Diastolic BP (mmHg), median (IQR)	54 (44-64)	52 (45-62)	0.864
Heart rate (beat/min), median (IQR)	91 (82-110)	93 (84-112)	0.381
Lactate (mmol/L), median (IQR)	1.225 (0.890-2.175)	3.760 (2.330-5.890)	<0.001
CRP (mg/L), median (IQR)	149 (99-203)	156 (89-244)	0.737
PCT (ng/mL), median (IQR)	4.76 (1.27-15.30)	9.43 (2.18-79.34)	0.359
APACHE II score, median (IQR)	17 (13-22)	21 (15-26)	0.015
SOFA score, median (IQR)	7 (5-10)	11 (9-14)	<0.001
NT-proBNP (pg/mL), median (IQR)	442 (208-2129)	983 (534-2310)	0.053
hs-TnI (ng/mL), median (IQR)	0.328 (0.151-1.854)	1.030 (0.540-2.780)	0.004
CK-MB (ng/mL), median (IQR)	5.74 (3.19-12.07)	11.71 (3.08-19.65)	0.350
Myoglobin (μg/L), median (IQR)	154 (89-347)	207 (144-456)	0.057