Effect of Garlic Organic Sulfides on Gene Expression Profiling in HepG2 Cells and Its Biological Function Analysis by Ingenuity Pathway Analysis System and Bio-Plex-Based Assays

Table 2

Changes in gene expression of drug metabolizing enzymes and transporters in DSs-treated cells.

Gene symbol	Gene title	Fold	Change
Detoxification: phase I drug
FMO5	Flavin containing monooxygenase 5	3.42	Down
		2.82
		3.58
NCF2	Neutrophil cytosolic factor 2 (65 kDa, chronic granulomatous disease, autosomal 2)	4.29	Up
		3.88
		3.16
Detoxification: phase II and antioxidant proteins
SQSTM1	Sequestosome 1	2.32	Up
		2.46
		2.20
HMOX1	Heme oxygenase (decycling) 1	2.01	Up
		2.22
		2.65
GCLC	Glutamate-cysteine ligase, catalytic subunit	2.32	Up
		2.51
		2.49
GCLM	Glutamate-cysteine ligase, modifier subunit	2.36	Up
		2.40
		2.58
Detoxification: phase III
SLC2A2	Solute carrier family 2 (facilitated glucose transporter), member 2	2.17	Down
		3.24
		3.01
SLC6A6	Solute carrier family 6 (neurotransmitter transporter, taurine), member 6	3.18	Up
		3.82
		3.17