Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer

<div>ZQT reduced MDSC population in TME by inducing intensive apoptosis in MDSCs. (a) MDSCs (CD11b<sup>+</sup> Gr-1<sup>+</sup>) were isolated from tumor tissue using the MojoSort Mouse Isolation Kit, and their purity was determined using flow cytometry analysis. (b, c) The proliferation of MDSCs isolated from ZQT or normal saline-treated tumor-bearing mice were detected by IF staining of Ki67 (scale bar: 20 <i>μ</i>M). (d) Representative apoptosis analysis of MDSCs isolated from tumor tissue by flow cytometry stained with Annexin V and PI. (e) Percentage of survival and apoptotic MDSCs isolated from normal saline or ZQT-treated mice. 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Mediators of Inflammation

fig5

Figure 5

Figure 5: Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer 

Figure 5 | Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer 