Review Article
MicroRNA-155: Regulation of Immune Cells in Sepsis
Table 1
Targeted genes of miR-155 that have been experimentally confirmed.
| No. | Target gene | Function |
| 1 | SOCS1 | Regulator of cytokine signal transduction | 2 | CEBPB | Related to the regulation of proinflammatory cytokines during macrophage activation and the acute phase response | 3 | TP53INP1 | Proapoptotic stress-induced p53 target gene | 4 | INPP5D/SHIP1 | Negative regulator of cell proliferation and survival | 5 | FOXO3 | Tumor suppressor | 6 | BACH1 | Transcription regulator protein | 7 | AGTR1 | Mediates the major cardiovascular effects of angiotensin II | 8 | TAB2 | Activator of MAP3K7/TAK1 | 9 | SMAD2 | Mediates the signal of the transforming growth factor- (TGF-) β | 10 | SMAD5 | Modulates signals of bone morphogenetic proteins (BMPs) | 11 | JARID2 | Organ development | 12 | SPI1/PU.1 | Myeloid and B-lymphoid cell development | 13 | ETS1 | Related to the differentiation and development of immune cells | 14 | E2F2 | Regulation of cell cycle and tumor suppressor protein | 15 | SIRT1 | Cellular regulation related protein deacetylating enzyme |
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