A Synthetic Curcuminoid Analogue, 2,6-Bis-4-(Hydroxyl-3-Methoxybenzylidine)-Cyclohexanone (BHMC) Ameliorates Acute Airway Inflammation of Allergic Asthma in Ovalbumin-Sensitized Mice

Figure 4

The effects of BHMC on the infiltration of inflammatory cells in peribronchial and perivascular regions of OVA-induced mice. After BALF was collected, the lungs and trachea of the mice ( per group) were processed into tissue sections and stained with H&E for the evaluation of cellular infiltration. The representative images of lung sections from the (a) OVA group, (b) PBS group, (c) 0.1 mg/kg BHMC group, (d) 1 mg/kg BHMC group, (e) 10 mg/kg BHMC group, and (f) DEX group. The inflammatory cells are indicated by the white arrows. Representative images of lung sections were taken at 400x magnification (40x for objective lens and 10x for ocular lens) using a light microscope. The results are also expressed quantitatively by counting the number of infiltrated cells at the (g) peribronchial region, (h) perivascular region, and (i) total for both peribronchial and perivascular regions. The values are expressed as . c: , b: , and a: , significantly different from the OVA group. A: , significantly different from the N group.

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