Postoperative Pulmonary Hemodynamics and Systemic Inflammatory Response in Pediatric Patients Undergoing Surgery for Congenital Heart Defects
Table 5
Inflammatory markers in groups defined according to immediate postoperative pulmonary hemodynamics.
()
()
value
Before surgery
Post-CPB
Before surgery
Post-CPB
Within subjects
Between groups
4 h
24 h
4 h
24 h
CD40L (upi)
4310 (2740-8359)
1898 (1178-2993)
2307 (1585-4034)
5916 (3162-6983)
2142 (1263-5321)
2760 (1315-4373)
<0.001
0.873
G-CSF (upi)
391 (154-800)
814 (360-1397)
401 (247-619)
689 (294-923)
1234 (766-1949)
679 (343-1597)
<0.001
0.040
GROα (upi)
1588 (1269-2980)
1191 (684-1353)
741 (443-1476)
1796 (1189-2947)
1594 (683-2828)
1210 (646-1670)
<0.001
0.292
IL-1RA (upi)
1210 (518-2249)
13140 (9524-18184)
4662 (1770-6574)
1925 (1070-2633)
18853 (14058-21786)
7036 (4654-12461)
<0.001
0.020
IL-6 (upi)
281 (141-637)
826 (368-1215)
601 (330-1071)
477 (225-1210)
2056 (1010-2839)
961 (450-2181)
<0.001
0.003
IL-8 (upi)
279 (146-403)
292 (169-621)
227 (144-448)
317 (155-655)
511 (267-864)
269 (189-610)
0.014
0.167
IL-16 (upi)
564 (261-1083)
1241 (1001-2715)
908 (349-1218)
578 (448-1518)
2768 (1529-3923)
1133 (635-2878)
<0.001
0.155
IP-10 (upi)
904 (410-1808)
1466 (637-2723)
659 (166-1122)
824 (623-2033)
3186 (1015-4080)
702 (186-2109)
<0.001
0.305
MCP-1 (upi)
381 (230-786)
447 (323-830)
364 (254-631)
560 (246-962)
881 (610-1269)
508 (241-1100)
0.002
0.178
MIF (upi)
5514 (4113-7055)
7117 (6604-9722)
5587 (3662-8508)
6078 (5192-7330)
9010 (7209-11057)
6753 (5465-8794)
<0.001
0.299
Serpin E1 (upi)
44650 (35485-57863)
37559 (30688-46958)
34719 (27139-40310)
52910 (40782-62429)
44831 (32830-53588)
40841 (35076-51601)
<0.001
0.086
RANTES (upi)
64525 (50627-81348)
50828 (39911-78459)
46564 (36403-66291)
68037 (59861-74569)
51934 (42454-68576)
48699 (33868-60721)
<0.001
0.956
SDF-1 (upi)
4123 (3615-6061)
3807 (2486-7486)
2668 (2098-4702)
4695 (3031-5795)
4797 (4031-7014)
3566 (2980-4947)
0.002
0.734
IL-21 (upi)
338 (152-589)
349 (257-558)
321 (211-585)
658 (344-949)
562 (353-912)
479 (278-834)
0.181
0.047
MPV (fL)
9.40 (8.65-9.80)
9.20 (8.65-9.85)
9.80 (9.20-10.30)
10.00 (9.30-10.85)
9.40 (9.05-10.00)
10.30 (9.75-10.85)
<0.001
0.018
NLR
0.54 (0.38-0.81)
6.83 (4.23-9.41)
5.14 (3.54-9.17)
0.77 (0.43-1.40)
6.50 (3.85-16.72)
7.09 (4.82-9.28)
<0.001
0.148
CRP (mg/L)
2.62 (1.27-4.99)
2.05 (1.56-3.20)
61.99 (51.09-78.33)
1.54 (0.90-3.39)
3.05 (2.01-4.35)
69.12 (55.62-82.65)
<0.001
0.942
Shown are the markers for which significant differences (within subjects and/or between groups) were observed. Results are presented as median with interquartile range. Levels of proteins obtained by chemiluminescence are given in units of pixel intensity (upi). Data were analyzed after Box-Cox transformation using the general linear model for repeated measures. PAP/SAPIPO: pulmonary/systemic mean arterial pressure ratio, mean of first 4 values (2-hour intervals) obtained in the postoperative care unit; CPB: cardiopulmonary bypass; CRP: C-reactive protein; MPV: mean platelet volume; NLR: neutrophil to lymphocyte ratio.
