Research Article
lnc-MRGPRF-6:1 Promotes M1 Polarization of Macrophage and Inflammatory Response through the TLR4-MyD88-MAPK Pathway
Figure 4
Knockout of lnc-MRGPRF-6:1 inhibits the formation of M1 macrophage and reduces the secretion of inflammatory cytokines. (a–c, i–k) The mRNA level of CXCL10, CXCL11, and IL-1β in M1-type macrophage was detected by RT-qPCR. (g, h, l, m) The expression of CCL17 and ARG1 in M2-type macrophage. (d, e) The protein levels of TNF-α and TNF-β in M1-type macrophage were detected by ELISA. (f) The expression of IL-10 in M2-type macrophage. ns: not statistically significant; , , , and .
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