Roles Played by the PI3K/Akt/HIF-1α Pathway and IL-17A in the Chinese Subtype of Chronic Sinusitis with Nasal Polyps

Figure 2

The activity of the PI3K/Akt/HIF-1α pathway in nasal polyps. (a) The protein levels of HIF-1α, p-Akt, and PI3K were detected by the WB method. Among them, 27, 33, 44, 72, 75, 81, 84, 88, and control 1-10 were the control groups, and the rest were the experimental groups. (b) The protein levels of HIF-1α, p-Akt, and PI3K in different groups. Among them, p-Akt and PI3K protein levels in the polyp group were significantly increased, compared with the control group. and . The HIF-1α protein level was not significantly different from that observed in control tissues. . (c) The HIF-1α mRNA expression level in nasal polyp tissues of CRSwNP patients was significantly higher than that in the control group. . , .

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