Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury

Table 1

Studies consistent with the purpose of this study.

Authors	Dosage of PG	Effects
Deng et al.	1.0 mg/kg	Reduces neuroinflammation, reduces the extent of cerebral edema, and promotes neurological recovery
Yonutas et al.	10 mg/kg	Restores mitochondrial dysfunction and increase mitochondrial bioenergetics
Liu et al.	10 mg/kg	Promotes dopaminergic neuronal survival and locomotor functional recovery
Yi et al.	10, 20, and 40 mg/kg	Reduces cerebral edema and inflammation by downregulating NLRP3-related inflammasomes
Das et al.	2 mg/kg	Reduces neuroinflammation in the brain by decreasing inflammatory cytokine production prior to hMSC transplantation
Sauerbeck et al.	10 mg/kg	Protects mitochondria, reduces inflammation, minimizes the cortical lesion, and improves cognitive function
Qiu et al.	1.0 and 10.0 mg/kg	Decreases the levels of inflammatory cytokines via upregulating PPARγ
Pilipović et al.	1 mg/kg	Reduces cortical oxidative damage, increased antioxidant defense, and had limited anti-inflammatory effect
Thal et al.	1 mg/kg	Reduces brain contusion volume; suppressed cerebral inflammation by reducing TNF-α, IL1-β, and IL-6 gene expression in brain tissue and simultaneous PPAR-c inhibition