IFN-α-2b Reduces Postoperative Arthrofibrosis in Rats by Inhibiting Fibroblast Proliferation and Migration through STAT1/p21 Signaling Pathway

<div>IFN-α-2b inhibited fibroblast proliferation and extracellular matrix secretion. (a) CCK-8 assay showed that IFN-α-2b inhibited fibroblast activity in a concentration- and time-dependent manner. (b) Flow cytometry analysis of cell cycle distribution showed that fibroblasts were arrested in the S phase after 48 hours of IFN-α-2b treatment. (c) The expression images of α-SMA and collagen I in cells treated with IFN-α-2b for 48 hours were observed under fluorescence microscope.</div>

Mediators of Inflammation

fig4

Figure 4

Figure 4: IFN-α-2b Reduces Postoperative Arthrofibrosis in Rats by Inhibiting Fibroblast Proliferation and Migration through STAT1/p21 Signaling Pathway

Figure 4 | IFN-α-2b Reduces Postoperative Arthrofibrosis in Rats by Inhibiting Fibroblast Proliferation and Migration through STAT1/p21 Signaling Pathway 