Mediators of Inflammation

Macrophages and Neutrophils: Regulation of the Inflammatory Microenvironment in Autoimmunity and Cancer


Publishing date
15 Apr 2016
Status
Published
Submission deadline
27 Nov 2015

1Technion & Carmel Medical Center, Haifa, Israel

2Netherlands Cancer Institute, Amsterdam, Netherlands

3Hebrew University, Jerusalem, Israel

4University of Sheffield, Sheffield, UK

5University of Florence, Florence, Italy


Macrophages and Neutrophils: Regulation of the Inflammatory Microenvironment in Autoimmunity and Cancer

Description

The pathophysiology of both autoimmune and cancer diseases involves innate immune cells, particularly macrophages and neutrophils that demonstrate high plasticity. Those are recruited by different mediators secreted from tissue or tumor cells, which sustain their survival and reprogram them to secrete factors that promote disease progression.

In tumors, the contribution of M2-polarized tumor-associated macrophages (TAMs) and of the recently identified N2-polarized tumor-associated neutrophils (TANs) has been described. These cell subsets expand with tumor progression and secrete increased amounts of proangiogenic, prometastatic, and immunosuppressive mediators to promote tumor growth and metastasis. However, the details of their interaction with other cell types that regulates their activity and their ability to generate different microenvironmental niches in the primary tumor and in the metastatic site have not been fully elucidated.

Macrophages play a pathogenic role in autoimmune diseases, and macrophage polarization can be altered at different stages of the disease, or both M1- and M2-macrophages can coexist in the hypoxic microenvironment, as recently was observed in rheumatoid arthritis. The balance between differently polarized macrophages could determine the course of the disease, and modulation of this balance could become a therapeutic goal. Following the late discovery of TANs in tumors, a role for neutrophils is now gaining more importance in the pathophysiology of autoimmune diseases

We invite investigators to contribute original research and review articles that address the mechanisms by which macrophages and neutrophils contribute to the progression of autoimmune diseases, tumor growth, and metastasis. Comparison between autoimmune diseases and cancer could highlight the similarities and differences between the phenotypes and functions of macrophages and neutrophils. Higher priority will be given to papers exploring or discussing the interactions and possible cooperation between these two cell types.

Potential topics include, but are not limited to:

  • Monocyte, macrophages, and neutrophils phenotyping: advances and limitations
  • TAMs and TANs recruitment into the tumor and the premetastatic niche
  • Polarization and regulation of TAMs and TANs in different niches of the inflammatory microenvironment
  • Macrophages and neutrophils as sensors of their inflammatory microenvironment
  • Effect of tissue/tumor cells interactions with macrophages and neutrophils on their activity
  • Cooperation between macrophages and neutrophils in the inflammatory microenvironment
  • Therapeutic interventions that change the macrophage or neutrophil polarization and function (e.g., chemotherapy, “biologics” as antibodies)

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 5894347
  • - Editorial

Macrophages and Neutrophils: Regulation of the Inflammatory Microenvironment in Autoimmunity and Cancer

Michal A. Rahat | Seth B. Coffelt | ... | Amedeo Amedei
  • Special Issue
  • - Volume 2016
  • - Article ID 5230219
  • - Review Article

Immune Cells in Cancer Therapy and Drug Delivery

Ceren Eyileten | Kinga Majchrzak | ... | Tomasz P. Rygiel
  • Special Issue
  • - Volume 2016
  • - Article ID 8489251
  • - Review Article

Double Roles of Macrophages in Human Neuroimmune Diseases and Their Animal Models

Xueli Fan | Hongliang Zhang | ... | Tao Jin
  • Special Issue
  • - Volume 2016
  • - Article ID 2053646
  • - Review Article

The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases

Antje Egners | Merve Erdem | Thorsten Cramer
  • Special Issue
  • - Volume 2016
  • - Article ID 8026494
  • - Research Article

IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin

Zhi-Yong Wang | Jun-Ai Zhang | ... | Jixin Zhong
  • Special Issue
  • - Volume 2016
  • - Article ID 2853040
  • - Research Article

GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway

Yajing Wang | Ping Lu | ... | Rong Hu
  • Special Issue
  • - Volume 2016
  • - Article ID 4375120
  • - Review Article

Parallel Aspects of the Microenvironment in Cancer and Autoimmune Disease

Michal A. Rahat | Jivan Shakya
  • Special Issue
  • - Volume 2016
  • - Article ID 9012369
  • - Review Article

Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies

Bruno Sainz | Emily Carron | ... | Heather L. Machado
  • Special Issue
  • - Volume 2016
  • - Article ID 6058147
  • - Review Article

Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment

Jaehong Kim | Jong-Sup Bae
  • Special Issue
  • - Volume 2016
  • - Article ID 3494608
  • - Review Article

Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer

Mario Orozco-Morales | Giovanny Soca-Chafre | ... | Oscar Arrieta
Mediators of Inflammation
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Acceptance rate41%
Submission to final decision79 days
Acceptance to publication38 days
CiteScore3.570
Impact Factor3.545
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