Mediators of Inflammation

Posttraumatic Immune Response and Its Modulation


Publishing date
02 Mar 2012
Status
Published
Submission deadline
02 Sep 2011

1Trauma Department, Hannover Medical School, Carl Neuberg Straße, 130625 Hannover, Germany

2Department of Trauma and Hand Surgery, Düsseldorf University Hospital, Moorenstraße, 540225 Düsseldorf, Germany

3Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstraße 13, 1200 Vienna, Austria

4Department of Trauma Surgery, UMC Utrecht, Heidelberglaan 100, G04.231, 3584 CX Utrecht, The Netherlands


Posttraumatic Immune Response and Its Modulation

Description

Following accidental trauma, an inflammatory response is induced involving hormonal, metabolic, and immunological mediators. This posttraumatic immune response is a physiological process required for tissue repair and regulation of the healing process. An overwhelming response after major trauma causing a disbalance between pro- and anti-inflammatory mediators resulting in complications like an increased susceptibility to infection, sepsis, and the Multiorgan Dysfunction Syndrome (MODS).

Following major trauma, a local release of mediators such as, for example, kinins, acid metabolites, and histamine increases the capillary permeability resulting in tissue edema and local infiltration of immunocompetent cells. Intrinsic leukocytes and affected endothelial cells produce and release pro- and anti-inflammatory cytokines acting locally as well as on remote cells in different organs like liver and lung.

Priming and activation of leukocytes in peripheral blood trigger the systemic immune response eventually leading to inflammatory complications. On the other hand, anergy of leukocytes may lead to infectious complications. Therefore, profound knowledge of this response is a major interest in order to anticipate and control potential complications like infection, sepsis, and the Multiorgan Dysfunction Syndrome.

The special issue will publish clinical and experimental research work dealing with characterization, modulation, and diagnosis of the above mentioned inflammation-mediated trauma response with special focus on the role of inflammatory mediators. Potential topics include, but are not limited to:

  • Influence of hypothermia on the posttraumatic immune response
  • Acute lung injury
  • Modulation of the immune response after trauma and envenomation
  • Stratification of the immune response by inflammatory mediators
  • Novel markers of the posttraumatic immune response

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 731563
  • - Editorial

Posttraumatic Immune Response and Its Modulation

Frank Hildebrand | Sascha Flohe | ... | Michael Frink
  • Special Issue
  • - Volume 2012
  • - Article ID 435463
  • - Clinical Study

Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period

M. Brumann | T. Kusmenkov | ... | V. Bogner
  • Special Issue
  • - Volume 2012
  • - Article ID 762840
  • - Review Article

Facts and Fiction: The Impact of Hypothermia on Molecular Mechanisms following Major Challenge

Michael Frink | Sascha Flohé | ... | Frank Hildebrand
  • Special Issue
  • - Volume 2012
  • - Article ID 536156
  • - Clinical Study

Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma

Birgit Auner | Emanuel V. Geiger | ... | Borna Relja
  • Special Issue
  • - Volume 2012
  • - Article ID 136020
  • - Research Article

Systemic Inflammatory Effects of Traumatic Brain Injury, Femur Fracture, and Shock: An Experimental Murine Polytrauma Model

C. Probst | M. J. Mirzayan | ... | M. van Griensven
  • Special Issue
  • - Volume 2012
  • - Article ID 890816
  • - Research Article

A New Experimental Polytrauma Model in Rats: Molecular Characterization of the Early Inflammatory Response

Sebastian Weckbach | Mario Perl | ... | Markus Huber-Lang
  • Special Issue
  • - Volume 2012
  • - Article ID 509513
  • - Research Article

Immunophenotyping of Posttraumatic Neutrophils on a Routine Haematology Analyser

Kathelijne Maaike Groeneveld | Marjolein Heeres | ... | Leo Koenderman
  • Special Issue
  • - Volume 2012
  • - Article ID 152895
  • - Clinical Study

The Effect of Conventional and Mini-Invasive Cardiopulmonary Bypass on Neutrophil Activation in Patients Undergoing Coronary Artery Bypass Grafting

Martina Kolackova | Jan Krejsek | ... | Vladimir Lonsky
  • Special Issue
  • - Volume 2012
  • - Article ID 186709
  • - Research Article

Effects of Trauma-Hemorrhage and IL-6 Deficiency on Splenic Immune Function in a Murine Trauma Model

P. Mommsen | T. Barkhausen | ... | C. Neunaber
  • Special Issue
  • - Volume 2012
  • - Article ID 204250
  • - Research Article

Distinct Proteasome Subpopulations in the Alveolar Space of Patients with the Acute Respiratory Distress Syndrome

S. U. Sixt | R. Alami | ... | J. Peters
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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