Mediators of Inflammation

Sphingolipids in Inflammation


Status
Published

Lead Editor

1Research Center of Biochemical-Specialized Analyses (CRABioN), Perugia, Italy

2Russian Academy of Sciences, Moscow, Russia

3Institute of Clinical Pharmacology, Frankfurt, Germany


Sphingolipids in Inflammation

Description

Sphingolipids are a class of bioactive lipids made up of long-chain sphingoid bases vital for cell life. The main sphingolipids include ceramide, ceramide-1-phosphate, glucosylceramide, sphingomyelin, sphingosine, and sphingosine-1-phosphate. In the past, sphingolipids were thought to be merely structural components of cellular membranes. In recent years, they have been described to be molecules involved in signal transduction at cellular and nuclear level. Thus, sphingolipids are now known to mediate cell proliferation, differentiation, apoptosis, cell migration, stress response, neuronal plasticity, angiogenesis, and cancer. Additionally, they are implicated in immune function and inflammatory diseases.

This special issue aims to provide a picture on recent advances in sphingolipid research from leading scientists throughout the world which offers important information on understanding of sphingolipid involvement in inflammation as well as on the identification of new targets for innovative drug treatments.

We invite authors to contribute original research articles, as well as review articles, that will illustrate new technologies for sphingolipid detection and analysis, demonstrate the role of sphingolipids in the regulation of inflammatory mediators in complex ways to promote or inhibit inflammation, clarify the implication of sphingolipid on inflammation component of bowel, spinal cord, lung, brain, kidney, heart, liver, and uterus and other diseases, and identify sphingolipids as predictive and prognostic biomarkers of inflammation.

Potential topics include but are not limited to the following:

  • Recent advances in biochemical and microscopy analysis of sphingolipids
  • Identification of new mechanisms of inflammation sphingolipid-mediated
  • Involvement of sphingolipids in the regulation of inflammatory mediators
  • Role of sphingolipids in different diseases
  • Identification of sphingolipids as biomarkers for innovative therapy strategies
  • Sphingolipid pathway as new pharmacological target in inflammatory diseases
  • Sphigolipid agonists in the clinical trials

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 7464702
  • - Editorial

Sphingolipids in Inflammation

Elisabetta Albi | Alice Alessenko | Sabine Grösch
  • Special Issue
  • - Volume 2018
  • - Article ID 5378284
  • - Review Article

The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response

Sabine Grösch | Alice V. Alessenko | Elisabetta Albi
  • Special Issue
  • - Volume 2017
  • - Article ID 5187368
  • - Research Article

Nuclear Translocation of SGPP-1 and Decrease of SGPL-1 Activity Contribute to Sphingolipid Rheostat Regulation of Inflammatory Dendritic Cells

Anja Schwiebs | Dominique Thomas | ... | Heinfried H. Radeke
  • Special Issue
  • - Volume 2017
  • - Article ID 1730245
  • - Research Article

Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells

Domitilla Schiumarini | Nicoletta Loberto | ... | Massimo Aureli
  • Special Issue
  • - Volume 2017
  • - Article ID 7685142
  • - Review Article

S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling

Ashok Kumar | Jesus Zamora-Pineda | ... | Julie D. Saba
  • Special Issue
  • - Volume 2017
  • - Article ID 2470950
  • - Research Article

Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells

Samuela Cataldi | Cataldo Arcuri | ... | Elisabetta Albi
  • Special Issue
  • - Volume 2017
  • - Article ID 4806541
  • - Review Article

The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer

Nitai C. Hait | Aparna Maiti
  • Special Issue
  • - Volume 2017
  • - Article ID 5301312
  • - Research Article

Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats

Liangrong Wang | Feifei Chen | ... | Xiangqing Xiong
  • Special Issue
  • - Volume 2017
  • - Article ID 5984819
  • - Research Article

Paradoxical Association of Postoperative Plasma Sphingosine-1-Phosphate with Breast Cancer Aggressiveness and Chemotherapy

Rajesh Ramanathan | Ali Raza | ... | Kazuaki Takabe
  • Special Issue
  • - Volume 2017
  • - Article ID 2076239
  • - Review Article

Clinical Impact of Sphingosine-1-Phosphate in Breast Cancer

Junko Tsuchida | Masayuki Nagahashi | ... | Toshifumi Wakai
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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