Mediators of Inflammation

CD4+T Helper Cell Plasticity in Infection, Inflammation, and Autoimmunity


Status
Published

Lead Editor

1University Medical Center Hamburg-Eppendorf Martinistr, Hamburg, Germany

2Yale University, New Haven, USA

3Albany Medical Center, Albany, USA

4Istituto Nazionale di Genetica Molecolare (INGM), Milan, Italy

5Universita degli Studi di Milano (UNIMI), Milan, Italy


CD4+T Helper Cell Plasticity in Infection, Inflammation, and Autoimmunity

Description

CD4+ T helper cells have been classically divided into different lineages. However recent data have challenged this paradigm: both T helper cell instability (they can cease to express their respective signature cytokine) and plasticity (they can start expressing cytokines typical of other lineages) have been observed. Furthermore this process seems to play a major role during infection, chronic inflammation, and carcinogenesis. However the factors controlling this phenomenon have only recently been uncovered.

We invite authors to contribute original research articles as well as review articles that will illustrate and stimulate the continued effort to understanding the mechanisms regulating T helper cell plasticity and instability and the consequences in different diseases.

Potential topics include, but are not limited to:

  • Recent discoveries of T helper cell plastic and instability in infection, autoimmunity, chronic inflammation, and carcinogenesis
  • Mechanism regulating T helper cell plasticity and instability
  • Consequences of T helper cell plasticity and instability in diseases.
  • Potential way to therapeutically manipulate T helper cell plasticity instability
  • T helper cell plasticity and instability in human diseases and in T cell therapies

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 7083153
  • - Editorial

CD4+ T Helper Cell Plasticity in Infection, Inflammation, and Autoimmunity

Samuel Huber | Nicola Gagliani | ... | Flavio Caprioli
  • Special Issue
  • - Volume 2016
  • - Article ID 5393894
  • - Review Article

CD4+ T Cell Fate in Glomerulonephritis: A Tale of Th1, Th17, and Novel Treg Subtypes

Christan F. Krebs | Oliver M. Steinmetz
  • Special Issue
  • - Volume 2016
  • - Article ID 6309219
  • - Review Article

Balancing Inflammation: The Link between Th17 and Regulatory T Cells

Maggie L. Diller | Ragini R. Kudchadkar | ... | Mandy L. Ford
  • Special Issue
  • - Volume 2016
  • - Article ID 9523628
  • - Review Article

Thymic and Postthymic Regulation of Naïve CD4+ T-Cell Lineage Fates in Humans and Mice Models

José E. Belizário | Wesley Brandão | ... | Jean Pierre Peron
  • Special Issue
  • - Volume 2016
  • - Article ID 6131234
  • - Research Article

Th17 Cell Response in Mice following Motor Nerve Injury

Allen Ni | Tao Yang | ... | Junping Xin
  • Special Issue
  • - Volume 2016
  • - Article ID 2974605
  • - Research Article

Reduced Numbers and Impaired Function of Regulatory T Cells in Peripheral Blood of Ischemic Stroke Patients

Johanna Ruhnau | Juliane Schulze | ... | Alexander Dressel
  • Special Issue
  • - Volume 2016
  • - Article ID 1937564
  • - Research Article

T Cell Response in Patients with Implanted Biological and Mechanical Prosthetic Heart Valves

L. Barbarash | I. Kudryavtsev | ... | A. Golovkin
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
 Submit