Mediators of Inflammation

Live or Die: Choice Mechanisms in Stressed Cells


Publishing date
15 May 2015
Status
Published
Submission deadline
26 Dec 2014

Lead Editor

1Sapienza University of Rome, Rome, Italy

2Danish Cancer Society Research Center, Copenhagen, Denmark

3Institute of Oncology, Barcelona, Spain

4VA Medical Center, Washington, USA


Live or Die: Choice Mechanisms in Stressed Cells

Description

Responses of cells to stress include a wide range of molecular processes, induced by microenvironmental changes, which damage the structure and function of macromolecules. Depending on the kind, the severity, and the duration of stress encountered, cells respond by modulating signaling pathways leading to repair, to adaption, or to cell death. Such different choices have crucial effects on tissue homeostasis. Among cellular responses to stress, a prolonged inflammation may occur, ultimately leading to several pathological conditions, including cancer.

This special issue focuses on the regulation of life or death decisions under stressful conditions.

Potential topics include, but are not limited to:

  • Types of stress:
    • Metabolic stress (including pathogens and toxins)
    • Oxidative stress (including hypoxic stress)
    • Endoplasmic reticulum (ER) stress
    • Age-related stress
    • Inflammatory stress
  • Cell responses: death or survival:
    • Apoptosis
    • Necroptosis
    • Autophagy
    • Pyroptosis
  • Cell death and survival pathways in cancer

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 454863
  • - Editorial

Live or Die: Choice Mechanisms in Stressed Cells

Francesco Cecconi | Laura Soucek | ... | Elio Ziparo
  • Special Issue
  • - Volume 2015
  • - Article ID 537853
  • - Research Article

Postmitotic Expression of SOD1G93A Gene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation

Martina Martini | Gabriella Dobrowolny | ... | Antonio Musarò
  • Special Issue
  • - Volume 2015
  • - Article ID 640631
  • - Research Article

Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI

Victoria Kegel | Elisa Pfeiffer | ... | Georg Damm
  • Special Issue
  • - Volume 2015
  • - Article ID 536238
  • - Research Article

S-Nitrosoglutathione Reductase Plays Opposite Roles in SH-SY5Y Models of Parkinson’s Disease and Amyotrophic Lateral Sclerosis

Salvatore Rizza | Claudia Cirotti | ... | Giuseppe Filomeni
  • Special Issue
  • - Volume 2015
  • - Article ID 204975
  • - Research Article

Anti-Inflammatory Effects of a Methanol Extract from the Marine Sponge Geodia cydonium on the Human Breast Cancer MCF-7 Cell Line

Susan Costantini | Giovanna Romano | ... | Maria Costantini
  • Special Issue
  • - Volume 2015
  • - Article ID 607957
  • - Research Article

Multidrug Resistance Protein-4 Influences Aspirin Toxicity in Human Cell Line

Isabella Massimi | Ambra Ciuffetta | ... | Maria Pia Felli
  • Special Issue
  • - Volume 2015
  • - Article ID 584758
  • - Review Article

Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?

Hemant Kumar | Dong-Kug Choi
  • Special Issue
  • - Volume 2015
  • - Article ID 259325
  • - Review Article

Cellular Response upon Stress: p57 Contribution to the Final Outcome

Marianna Nicoletta Rossi | Fabrizio Antonangeli
  • Special Issue
  • - Volume 2015
  • - Article ID 146282
  • - Review Article

Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

Margaret M. Mc Gee
  • Special Issue
  • - Volume 2015
  • - Article ID 604208
  • - Review Article

Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes

Gina Manda | Alexandru-Ionel Checherita | ... | Mihail Eugen Hinescu
Mediators of Inflammation
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Acceptance rate24%
Submission to final decision75 days
Acceptance to publication21 days
CiteScore7.000
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Impact Factor4.529
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