Mediators of Inflammation

Innate Immune Pathways in Host Defense


Publishing date
25 May 2012
Status
Published
Submission deadline
25 Nov 2011

1Department of Immunology, St. Jude Children’s Research Hospital, MS 351, Room E7004, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA

2Department of Biochemistry, Ghent University; VIB Department of Medical Protein Research, Albert Baertsoenkaai 3, 9000 Ghent, Belgium

3Department of Internal Medicine, The Ohio State University, Columbus, OH, USA


Innate Immune Pathways in Host Defense

Description

The innate immune system is a critical component of host defense against invading microbial pathogens. It is responsible for mounting proper inflammatory and repair responses that contribute to elimination of the invading pathogen, and for instructing the adaptive immune system to develop prolonged immunity against microbial pathogens. This is accomplished through regulation of transcriptional and posttranslational programs that culminate in the production of proinflammatory cytokines and chemokines, the induction of type I and II interferon responses, autophagy responses, and the induction of programmed cell death modes that eliminate infected host cells and expose intracellular pathogens to surveillance by the immune system.

We particularly take an interest in manuscripts that report on the relevance of innate immune cells and pathways in protection against viral, bacterial, and fungal pathogens, their roles in the induction of inflammatory and repair responses, therapy, or delineate the characteristics of innate immune pathways. Reviews and original papers that summarize the results of clinical, preclinical, or experimental setups analyzing molecules aimed at modifying innate immune pathways for therapeutic purposes are welcome. Moreover, papers dealing with criteria for optimal analysis and detection methods of innate immune parameters in the blood, leading to a guideline as a tool for clinical guidance, would be of great interest (specificity, sensitivity, reproducibility, robustness, objective read-out, potential for automated analysis, quantification, characterization of immune cell subpopulations, and proven clinical guidance). Potential topics include, but are not limited to:

  • Innate immune responses in clinical guidance for infectious disease
  • Targeting innate immune pathways for therapy
  • Regulation of innate immune pathways by microRNAs
  • Signaling pathways of the innate immune system
  • Innate immune mechanisms in plants and invertebrates
  • Role of natural killer cells in immune surveillance and viral clearance
  • The role of inflammasomes in anti-infectious immunity
  • The innate immune system in inflammatory chronic diseases

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 708972
  • - Editorial

Innate Immune Pathways in Host Defense

Thirumala-Devi Kanneganti | Mohamed Lamkanfi | Amal O. Amer
  • Special Issue
  • - Volume 2012
  • - Article ID 207398
  • - Research Article

The EGF Receptor and HER2 Participate in TNF-α-Dependent MAPK Activation and IL-8 Secretion in Intestinal Epithelial Cells

Humberto B. Jijon | Andre Buret | ... | Paul L. Beck
  • Special Issue
  • - Volume 2012
  • - Article ID 949157
  • - Review Article

Innate Immune Cells in Liver Inflammation

Evaggelia Liaskou | Daisy V. Wilson | Ye H. Oo
  • Special Issue
  • - Volume 2012
  • - Article ID 690643
  • - Review Article

Optimizing Dendritic Cell-Based Immunotherapy: Tackling the Complexity of Different Arms of the Immune System

Ilse Van Brussel | Zwi N. Berneman | Nathalie Cools
  • Special Issue
  • - Volume 2012
  • - Article ID 315941
  • - Review Article

Danger Signals Activating the Immune Response after Trauma

Stefanie Hirsiger | Hans-Peter Simmen | ... | Daniel Rittirsch
  • Special Issue
  • - Volume 2012
  • - Article ID 356494
  • - Review Article

Guilty Molecules, Guilty Minds? The Conflicting Roles of the Innate Immune Response to Traumatic Brain Injury

Sarah Claire Hellewell | Maria Cristina Morganti-Kossmann
  • Special Issue
  • - Volume 2012
  • - Article ID 607276
  • - Review Article

Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship

Giada Rossini | Cristina Cerboni | ... | Stefania Varani
  • Special Issue
  • - Volume 2012
  • - Article ID 684274
  • - Review Article

Lipopolysaccharides: From Erinyes to Charites

Alfredo Focà | Maria Carla Liberto | ... | Giovanni Matera
  • Special Issue
  • - Volume 2012
  • - Article ID 294070
  • - Research Article

Essential Role of Mast Cells in the Visceral Hyperalgesia Induced by T. spiralis Infection and Stress in Rats

Chang-Qing Yang | Yan-Yu Wei | ... | Li-Ping Duan
Mediators of Inflammation
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Acceptance rate14%
Submission to final decision136 days
Acceptance to publication27 days
CiteScore7.700
Journal Citation Indicator0.570
Impact Factor4.6
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