Mediators of Inflammation

Oxidized LDL in Inflammation: From Bench to Bedside


Publishing date
22 Nov 2013
Status
Published
Submission deadline
05 Jul 2013

Lead Editor

1Department of Immunology, School of Medicine, Bulent Ecevit University, Zonguldak, Turkey

2Department of Medical Biochemistry, School of Medicine, Karadeniz Technical University, Trabzon, Turkey

3Department of Genetics and Cell Biology, Maastricht University Medical Centre, Maastricht, The Netherlands


Oxidized LDL in Inflammation: From Bench to Bedside

Description

Since the discovery of oxidized low-density lipoprotein (Ox-LDL), over 6,000 articles have appeared on the topic with over 4000 articles appearing during the past decade. Numerous studies have documented that oxidized lipids as well as products derived from their decomposition have deleterious biological properties. A plethora of in vitro and animal studies, as well as human epidemiological studies, have supported the notion that oxidative processes and the formation of Ox-LDL might contribute to atherosclerosis. Ox-LDL is taken up by macrophages via scavenger receptors, such as SR-A1, SR-A2, and LOX-1. Oxidized LDL mediates many proatherogenic and proinflammatory pathways. Minimally modified LDL also induces proinflammatory effects in macrophages, which are mediated through toll-like receptor-4, including cytoskeletal rearrangements and macropinocytosis, generation of reactive oxygen species, survival of foam cells, and expression of inflammatory genes. We are interested in articles that explore aspects of oxidized LDL molecules in inflammation. Potential topics include, but are not limited to:

  • The role of oxidized LDL in chronic inflammation
  • The incidence of coronary artery disease in patients with inflammatory disorders
  • Relationship between atherosclerosis and chronic infection
  • Specific effects of oxidized LDL on macrophages in inflammation
  • Mouse models of oxidized LDL in inflammation
  • Oxidized LDL and ischemia-reperfusion injury
  • Involvement of oxidized LDL in autophagy and inflammasome activation
  • Intracellular signaling induced by oxidized LDL
  • Relationship between oxidized LDL and cellular senescence in inflammation
  • Involvement of oxidized LDL in apoptosis
  • Effects of oxidized LDL on gut microbiota

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/author/submit/journals/mi/oxldl/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 762759
  • - Editorial

Oxidized LDL in Inflammation: From Bench to Bedside

Ishak Ozel Tekin | Asım Orem | Ronit Shiri-Sverdlov
  • Special Issue
  • - Volume 2013
  • - Article ID 750742
  • - Research Article

Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men

Karim Zouaoui Boudjeltia | Cédric Delporte | ... | Thierry Roumeguère
  • Special Issue
  • - Volume 2013
  • - Article ID 312590
  • - Research Article

Plasmacytoid Dendritic Cell Response to CpG ODN Correlates with CXCL16 Expression and Is Inhibited by ox-LDL

Mayda Gursel | Dennis M. Klinman | Ihsan Gursel
  • Special Issue
  • - Volume 2013
  • - Article ID 612038
  • - Research Article

Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin

Filipa Mascarenhas-Melo | José Sereno | ... | Flávio Reis
  • Special Issue
  • - Volume 2013
  • - Article ID 714653
  • - Review Article

The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts

Giuseppe Maiolino | Giacomo Rossitto | ... | Lorenzo A. Calò
  • Special Issue
  • - Volume 2013
  • - Article ID 972347
  • - Clinical Study

Increased Serum ox-LDL Levels Correlated with Lung Function, Inflammation, and Oxidative Stress in COPD

Yongchun Shen | Ting Yang | ... | Fuqiang Wen
  • Special Issue
  • - Volume 2013
  • - Article ID 198193
  • - Research Article

Oxidized LDL Induces Alternative Macrophage Phenotype through Activation of CD36 and PAFR

Francisco J. Rios | Marianna M. Koga | ... | S. Jancar
  • Special Issue
  • - Volume 2013
  • - Article ID 181324
  • - Review Article

Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation

Montserrat Estruch | José Luis Sánchez-Quesada | ... | Sònia Benítez
  • Special Issue
  • - Volume 2013
  • - Article ID 761789
  • - Review Article

Oxidized LDL and LOX-1 in Experimental Sepsis

Nadia Al-Banna | Christian Lehmann
  • Special Issue
  • - Volume 2013
  • - Article ID 971579
  • - Review Article

Low-Density Lipoprotein Modified by Myeloperoxidase in Inflammatory Pathways and Clinical Studies

Cédric Delporte | Pierre Van Antwerpen | ... | Karim Zouaoui Boudjeltia
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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