Mediators of Inflammation

Oxidized LDL in Inflammation: From Bench to Bedside

Publishing date
22 Nov 2013
Submission deadline
05 Jul 2013

Lead Editor

1Department of Immunology, School of Medicine, Bulent Ecevit University, Zonguldak, Turkey

2Department of Medical Biochemistry, School of Medicine, Karadeniz Technical University, Trabzon, Turkey

3Department of Genetics and Cell Biology, Maastricht University Medical Centre, Maastricht, The Netherlands

Oxidized LDL in Inflammation: From Bench to Bedside


Since the discovery of oxidized low-density lipoprotein (Ox-LDL), over 6,000 articles have appeared on the topic with over 4000 articles appearing during the past decade. Numerous studies have documented that oxidized lipids as well as products derived from their decomposition have deleterious biological properties. A plethora of in vitro and animal studies, as well as human epidemiological studies, have supported the notion that oxidative processes and the formation of Ox-LDL might contribute to atherosclerosis. Ox-LDL is taken up by macrophages via scavenger receptors, such as SR-A1, SR-A2, and LOX-1. Oxidized LDL mediates many proatherogenic and proinflammatory pathways. Minimally modified LDL also induces proinflammatory effects in macrophages, which are mediated through toll-like receptor-4, including cytoskeletal rearrangements and macropinocytosis, generation of reactive oxygen species, survival of foam cells, and expression of inflammatory genes. We are interested in articles that explore aspects of oxidized LDL molecules in inflammation. Potential topics include, but are not limited to:

  • The role of oxidized LDL in chronic inflammation
  • The incidence of coronary artery disease in patients with inflammatory disorders
  • Relationship between atherosclerosis and chronic infection
  • Specific effects of oxidized LDL on macrophages in inflammation
  • Mouse models of oxidized LDL in inflammation
  • Oxidized LDL and ischemia-reperfusion injury
  • Involvement of oxidized LDL in autophagy and inflammasome activation
  • Intracellular signaling induced by oxidized LDL
  • Relationship between oxidized LDL and cellular senescence in inflammation
  • Involvement of oxidized LDL in apoptosis
  • Effects of oxidized LDL on gut microbiota

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


  • Special Issue
  • - Volume 2013
  • - Article ID 691023
  • - Research Article

Ox-LDL Promotes Migration and Adhesion of Bone Marrow-Derived Mesenchymal Stem Cells via Regulation of MCP-1 Expression

Fenxi Zhang | Congrui Wang | ... | Xianwei Wang
  • Special Issue
  • - Volume 2013
  • - Article ID 152786
  • - Review Article

LOX-1, OxLDL, and Atherosclerosis

Angela Pirillo | Giuseppe Danilo Norata | Alberico Luigi Catapano
  • Special Issue
  • - Volume 2013
  • - Article ID 925171
  • - Research Article

Activation of TRPV1 Prevents OxLDL-Induced Lipid Accumulation and TNF-α-Induced Inflammation in Macrophages: Role of Liver X Receptor α

Jin-Feng Zhao | Li-Chieh Ching | ... | Tzong-Shyuan Lee
  • Special Issue
  • - Volume 2013
  • - Article ID 624540
  • - Research Article

Low-Density Lipoproteins Oxidation and Endometriosis

Grzegorz Polak | Bartłomiej Barczyński | ... | Jan Kotarski
  • Special Issue
  • - Volume 2013
  • - Article ID 656570
  • - Research Article

Minimally Modified LDL Upregulates Endothelin Type A Receptors in Rat Coronary Arterial Smooth Muscle Cells

Jie Li | Lei Cao | ... | Yong-Xiao Cao
  • Special Issue
  • - Volume 2013
  • - Article ID 156053
  • - Research Article

Paraoxonase-1 Inhibits Oxidized Low-Density Lipoprotein-Induced Metabolic Alterations and Apoptosis in Endothelial Cells: A Nondirected Metabolomic Study

Anabel García-Heredia | Judit Marsillach | ... | Jordi Camps
  • Special Issue
  • - Volume 2013
  • - Article ID 862982
  • - Clinical Study

Levels of Oxidized LDL, Estrogens, and Progesterone in Placenta Tissues and Serum Paraoxonase Activity in Preeclampsia

Şerefden Açıkgöz | Ülkü Özmen Bayar | ... | Vildan Sümbüloğlu
Mediators of Inflammation
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Submission to final decision53 days
Acceptance to publication29 days
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