Mediators of Inflammation

Ion Channels in Inflammatory Processes: What Is Known and What Is Next?


Publishing date
18 Mar 2016
Status
Published
Submission deadline
30 Oct 2015

1Universidad del Desarrollo, Santiago, Chile

2Albert Einstein College of Medicine, New York, USA

3Murcia's BioHealth Research Institute, Murcia, Spain

4Universidad Andres Bello, Santiago, Chile


Ion Channels in Inflammatory Processes: What Is Known and What Is Next?

Description

Inflammation is the primary response of the immune system to infection or tissue injury. Ion channels in different immune cells are very important for the inflammatory processes. In this context, connexin (Cxs) and pannexins (Panx) channels and P2 receptors have central roles in the initiation and/or progression of inflammation in different tissues. Thus, cellular responses during inflammation can be initiated and/or enhanced by the opening of Cx and/or Panx channels, which in turn allow the release of ATP and other metabolites to the extracellular media. These can act as danger signals propagating the original inflammatory insult. Extracellular ATP can activate important intracellular signaling pathways through the activation of P2 receptors. However, it is yet not completely clear how these channels become active in these processes, how these channels can crosstalk, and how their pharmacological modulation may have a potential advantageous or beneficial therapeutic effect. We invite researchers to contribute with original as well as review articles that will help to understand the roles of ion channels in inflammation, in particular (but not exclusively) Cxs, Panx, and P2 receptors. We encourage authors to focus their contributions to the title of this special issue: what is known and what is next. Authors are encouraged to contact Guest Editors to discuss their contribution contents and plan prior to preparation or submission.

Potential topics include, but are not limited to:

  • Molecular mechanisms describing ion channel activation during inflammation
  • The importance of ion channel and P2 receptor activation in cell function during inflammation
  • The interplay of ion channels in inflammatory processes
  • The importance of extracellular ATP signaling in inflammation
  • Pharmacological modulation of ion channels in inflammation
  • New tools to influence ion channel activation

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 6245731
  • - Editorial

Ion Channels in Inflammatory Processes: What Is Known and What Is Next?

Mauricio A. Retamal | Michael V. L. Bennett | ... | Ricardo Fernandez
  • Special Issue
  • - Volume 2016
  • - Article ID 7852168
  • - Review Article

Manipulation of P2X Receptor Activities by Light Stimulation

Sang Seong Kim
  • Special Issue
  • - Volume 2015
  • - Article ID 497387
  • - Review Article

Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases

Monica Sala-Rabanal | Zeynep Yurtsever | ... | Tom J. Brett
  • Special Issue
  • - Volume 2015
  • - Article ID 362768
  • - Review Article

Proinflammatory Cytokines and Potassium Channels in the Kidney

Kazuyoshi Nakamura | Hikaru Hayashi | Manabu Kubokawa
  • Special Issue
  • - Volume 2015
  • - Article ID 148367
  • - Research Article

Lung Epithelial TRPA1 Transduces the Extracellular ROS into Transcriptional Regulation of Lung Inflammation Induced by Cigarette Smoke: The Role of Influxed Ca2+

An-Hsuan Lin | Meng-Han Liu | ... | Yu Ru Kou
  • Special Issue
  • - Volume 2015
  • - Article ID 124942
  • - Research Article

Modulation of Voltage-Gated Sodium Channels by Activation of Tumor Necrosis Factor Receptor-1 and Receptor-2 in Small DRG Neurons of Rats

M. Leo | S. Argalski | ... | T. Hagenacker
Mediators of Inflammation
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Acceptance rate13%
Submission to final decision140 days
Acceptance to publication24 days
CiteScore7.700
Journal Citation Indicator0.570
Impact Factor4.6
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