Mediators of Inflammation

Lipid Mediators in Skin Inflammation: Updates and Current Views


Publishing date
01 Dec 2010
Status
Published
Submission deadline
01 Jun 2010

1Department of Biomedical Sciences, University of Siena, Via Aldo Moro, 7-53100 Siena, Italy

2Lab. Tissue Engineering & Cutaneous Physiopathology, Istituto Dermopatico dell'Immacolata, IRCCS, Via Monti di Creta, 104-00167 Rome, Italy

3The Department of Oral Pathology, Radiology & Medicine, Dows Institute for Dental Research, University of Iowa, Iowa City, IA 52242, USA


Lipid Mediators in Skin Inflammation: Updates and Current Views

Description

The skin is a very peculiar organ, displaying biochemical and immunological features specific for a compartment continuously exposed to external and endogenous stimuli. Skin lipid composition is a mixture derived from keratinocyte membranes and sebum, including unique compounds such as squalene or specific bioactive sphingolipids, not only providing protection from environmental stressors, but also giving rise to by-products able to trigger, sustain, or terminate cutaneous inflammatory processes.

The aim of this special issue is to provide current advances on the role of skin lipids and of their oxidation by-products, namely, 4-hydroxynonenal, oxysterols, oxidized phospholipids among others, in the determinism and regulation of skin and mucosal tissue inflammation. Their function in the modulation of ROS, RNS, cytokine, and chemokine production and release, in DNA and protein oxidation, in gene expression, in the regulation of antioxidant and detoxifying enzymes, is under extensive investigation.

We invite authors to present original research articles as well as review articles that will add new information or review current status of research on the role of lipid molecules and their by-products in triggering, sustaining, and modulating inflammatory states of the cutaneous compartment. Lipid oxidation is a key mechanism involved in chronic inflammatory skin diseases, among which are psoriasis, acne, atopic and seborrheic dermatitis. Special focus will also be on the role of lipid mediators derived from oxidative processes and cell apoptotic membranes, in skin wound healing and in skin ageing. Among environmental and endogenous stressors modifying skin lipid targets, stress will be cast on cigarette smoke- ozone- and UV-driven lipid mediators of inflammation, generated by both environmental exposure and physiotherapy protocols, with attention to active principles for systemic and topical application, aimed at the prevention not only of sunburn but also to local and systemic immunological impairment, resulting in increased risk of photocarcinogenesis. Lipid modifications induced by resident and pathogenic microbial flora, affecting inflammatory status of the skin, will also deserve attention in view of the recent appraisal of plant extracts as inhibitors of skin lipoperoxidation and proinflammatory cytokines release. Finally, the effectiveness of dietary intervention in the modulation of the proinflammatory/anti-inflammatory effects of lipid mediators in the skin will need deeper investigation, awaiting more in vivo studies to gain clinical consensus. Reports on clinical studies investigating the roles of lipid mediators in psoriasis, atopic dermatitis, or other chronic inflammatory skin states, or in acute inflammation consequent to skin surgery, dermoesthetic procedures, severe burns, and so forth, will provide precious translational value to the issue.

Before submission, authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 398926
  • - Editorial

Lipid Mediators in Skin Inflammation: Updates and Current Views

Giuseppe Valacchi | Chiara De Luca | Philip W. Wertz
  • Special Issue
  • - Volume 2010
  • - Article ID 321494
  • - Review Article

Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli

Chiara De Luca | Giuseppe Valacchi
  • Special Issue
  • - Volume 2010
  • - Article ID 364823
  • - Review Article

Post-Genomics and Skin Inflammation

Daniela Braconi | Giulia Bernardini | Annalisa Santucci
  • Special Issue
  • - Volume 2010
  • - Article ID 858176
  • - Review Article

Lipid Mediators in Acne

Monica Ottaviani | Emanuela Camera | Mauro Picardo
  • Special Issue
  • - Volume 2010
  • - Article ID 342328
  • - Research Article

Effect of Dietary Conjugated Linoleic Acid Supplementation on Early Inflammatory Responses during Cutaneous Wound Healing

Na-Young Park | Giuseppe Valacchi | Yunsook Lim
  • Special Issue
  • - Volume 2010
  • - Article ID 861949
  • - Review Article

Redox Imbalance in T Cell-Mediated Skin Diseases

Saveria Pastore | Liudmila Korkina
  • Special Issue
  • - Volume 2010
  • - Article ID 535612
  • - Review Article

Lipid Disturbances in Psoriasis: An Update

Aldona Pietrzak | Anna Michalak-Stoma | ... | Jacek C. Szepietowski
  • Special Issue
  • - Volume 2010
  • - Article ID 230450
  • - Research Article

Examining the Genomic Influence of Skin Antioxidants In Vitro

James V. Gruber | Robert Holtz
  • Special Issue
  • - Volume 2010
  • - Article ID 413238
  • - Review Article

Nonsteroidal Anti-Inflammatory Drugs for Wounds: Pain Relief or Excessive Scar Formation?

Wen-Hsiang Su | Ming-Huei Cheng | ... | Peng-Hui Wang
  • Special Issue
  • - Volume 2010
  • - Article ID 610418
  • - Review Article

Ozone and Ozonated Oils in Skin Diseases: A Review

V. Travagli | I. Zanardi | ... | V. Bocci
Mediators of Inflammation
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Acceptance rate36%
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