Mediators of Inflammation

The Role of Inflammatory Mediators in Immune-to-Brain Communication during Health and Disease


Publishing date
12 Jul 2013
Status
Published
Submission deadline
22 Feb 2013

1Centre for Biological Sciences, University of Southampton, Southampton SO166YD, UK

2Neuroimmunology Group, Department of Functional and Systems Neurobiology, Instituto Cajal, CSIC, Madrid, Spain

3Department of Neuroscience, Center for Brain and Spinal Cord Repair, Columbus, OH 43210, USA


The Role of Inflammatory Mediators in Immune-to-Brain Communication during Health and Disease

Description

The field of neuroimmunology is providing growing evidence of active crosstalk between the immune system and the nervous system in health and during diverse pathological conditions. Experimental and clinical research now suggests that signaling from periphery to brain is important for maintaining homeostasis but also has the potential to impact on brain disease initiation or progression. Knowledge and understanding of the cellular and molecular mechanisms governing immune-to-brain bidirectional communication will provide key insights to better model neuroimmune communication, understand the clinical implications, and design better therapies for CNS disorders with an inflammatory component.

We invite authors to submit original research and review articles that aim to further understand the communication of the immune and nervous systems in health and disease. We are interested in articles that explore novel aspects of neuroimmunology in both experimental models and humans. Potential topics include, but are not limited to:

  • Role of cytokines, chemokines, or other inflammatory mediators in the regulation of basal nervous system physiology and activity
  • Advances in immune-to-brain communication during CNS disease, including neurodegenerative and/or neuroinflammatory/autoimmune disorders.
  • Communication of the immune and nervous systems during development and ageing
  • The impact of systemic inflammation during development and onset of CNS disease later in life
  • The role of the blood brain barrier in immune-to-brain communication
  • Role of the different cells (endothelial, microglia, pericytes, astrocytes, etc.) regulating behavioral, metabolic, or physiological changes in response to systemic immune activation
  • Function of pattern recognition receptors in immune-to-brain communication
  • Novel cellular and experimental models to understand neuroimmune communication

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/mi/brain/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 429231
  • - Editorial

The Role of Inflammatory Mediators in Immune-to-Brain Communication during Health and Disease

Diego Gomez-Nicola | Jessica Teeling | ... | Dennis D. Taub
  • Special Issue
  • - Volume 2013
  • - Article ID 320519
  • - Review Article

Immune Privilege as an Intrinsic CNS Property: Astrocytes Protect the CNS against T-Cell-Mediated Neuroinflammation

Ulrike Gimsa | N. Avrion Mitchison | Monika C. Brunner-Weinzierl
  • Special Issue
  • - Volume 2013
  • - Article ID 850714
  • - Clinical Study

Prognostic Value of Inflammatory Mediators in 1-Year Outcome of Acute Ischemic Stroke with Middle Cerebral Artery Stenosis

Xiping Gong | Xinying Zou | ... | Ka Sing Wong
  • Special Issue
  • - Volume 2013
  • - Article ID 898165
  • - Review Article

Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory

Yasunobu Arima | Daisuke Kamimura | ... | Masaaki Murakami
  • Special Issue
  • - Volume 2013
  • - Article ID 172986
  • - Review Article

Are Onconeural Antibodies a Clinical Phenomenology in Paraneoplastic Limbic Encephalitis?

Hongliang Zhang | Chunkui Zhou | ... | Tao Jin
  • Special Issue
  • - Volume 2013
  • - Article ID 271359
  • - Research Article

Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice

Steven Biesmans | Theo F. Meert | ... | Rony Nuydens
  • Special Issue
  • - Volume 2013
  • - Article ID 893521
  • - Review Article

Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation

Adam Aguirre | Carola J. Maturana | ... | Juan C. Sáez
  • Special Issue
  • - Volume 2013
  • - Article ID 952375
  • - Review Article

Cellular and Molecular Mediators of Neuroinflammation in the Pathogenesis of Parkinson’s Disease

Sandeep Vasant More | Hemant Kumar | ... | Dong-Kug Choi
  • Special Issue
  • - Volume 2013
  • - Article ID 519627
  • - Research Article

Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production

Sofia Fernanda Gonçalves Zorzella-Pezavento | Fernanda Chiuso-Minicucci | ... | Alexandrina Sartori
  • Special Issue
  • - Volume 2013
  • - Article ID 312476
  • - Research Article

The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis

Denis Grandgirard | Rahel Gäumann | ... | Stephen L. Leib
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.400
Journal Citation Indicator0.610
Impact Factor4.711
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