The field of neuroimmunology is providing growing evidence of active crosstalk between the immune system and the nervous system in health and during diverse pathological conditions. Experimental and clinical research now suggests that signaling from periphery to brain is important for maintaining homeostasis but also has the potential to impact on brain disease initiation or progression. Knowledge and understanding of the cellular and molecular mechanisms governing immune-to-brain bidirectional communication will provide key insights to better model neuroimmune communication, understand the clinical implications, and design better therapies for CNS disorders with an inflammatory component.

We invite authors to submit original research and review articles that aim to further understand the communication of the immune and nervous systems in health and disease. We are interested in articles that explore novel aspects of neuroimmunology in both experimental models and humans. Potential topics include, but are not limited to:

• Role of cytokines, chemokines, or other inflammatory mediators in the regulation of basal nervous system physiology and activity
• Advances in immune-to-brain communication during CNS disease, including neurodegenerative and/or neuroinflammatory/autoimmune disorders.
• Communication of the immune and nervous systems during development and ageing
• The impact of systemic inflammation during development and onset of CNS disease later in life
• The role of the blood brain barrier in immune-to-brain communication
• Role of the different cells (endothelial, microglia, pericytes, astrocytes, etc.) regulating behavioral, metabolic, or physiological changes in response to systemic immune activation
• Function of pattern recognition receptors in immune-to-brain communication
• Novel cellular and experimental models to understand neuroimmune communication

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/mi/brain/ according to the following timetable: