Mediators of Inflammation

Recruitment of Immune Cells into Inflamed Tissues: Consequences for Endothelial Barrier Integrity and Tissue Functionality


Status
Published

Lead Editor

1Cinvestav-IPN, Mexico City, Mexico

2Tufts University, Boston, USA

3William Harvey Research Institute, London, UK

4Sanquin Research Center, Amsterdam, Netherlands


Recruitment of Immune Cells into Inflamed Tissues: Consequences for Endothelial Barrier Integrity and Tissue Functionality

Description

Immune cell trafficking is a vital process of immune surveillance and proper immune responses to tissue injury or invading pathogens. Transmigrated leukocytes contribute to pathogen clearance and resolution of inflammation and are thus indispensable for tissue health. However, uncontrolled extravasation may provoke excessive release of proinflammatory cytokines, proteases, and reactive oxygen species that can induce endothelial dysfunction and tissue damage in various pathological inflammatory conditions including sepsis, autoimmune, and cardiovascular diseases. The leukocyte extravasation cascade requires expression/activation of adhesion receptors, coordinated activation of signalling pathways and cytoskeletal remodelling in all cell types involved. In vitroand in vivo data indicate that overactivated leukocytes are capable of inflicting considerable endothelial injury with increased permeability eventually causing tissue damage and organ failure. The complex nature of physiological and pathological leukocyte extravasation leaves investigators with many open questions regarding the mechanisms that control leukocyte-endothelial interaction during the extravasation cascade to ensure appropriate immune responses.

The purpose of this special issue is to publish high-quality original research papers as well as review articles addressing recent conceptual and/or methodological advances in the field of leukocyte extravasation and endothelial dysfunction during inflammatory diseases. Original articles are encouraged explaining mechanisms by which aberrant leukocyte responses cause endothelial barrier dysfunction and organ failure. Review articles are encouraged discussing questions that have recently been answered and problems that remain to be solved in the field of inflammatory immune cell recruitment.

Potential topics include, but are not limited to:

  • Leukocyte-endothelial receptor-ligand interactions
  • Endothelial regulation of T cell subset recruitment
  • Signal transduction pathways regulating the leukocyte extravasation cascade
  • Cytokine/chemokine-dependent microenvironmental priming of leukocytes
  • Mechanisms of leukocyte-induced endothelial hyperpermeability
  • Role of excessive leukocyte recruitment in organ failure during systemic inflammations
  • Leukocyte traffic in inflammatory diseases including autoimmune and cardiovascular diseases
  • Leukocyte-induced endothelial-mesenchymal transition and fibrosis
  • Actin dynamics in leukocytes and endothelial cells allowing the required morphological changes
  • Mechanisms determining the route of transmigration: trans- versus paracellular
  • Breaking barriers: how leukocytes cross the endothelium, pericytes, and basement membrane
  • Epidemiologic studies on inflammatory diseases caused by excessive leukocyte recruitment
  • Novel in vivo and in vitro models to study leukocyte-endothelial interactions
  • New methodological approaches to monitor immune cell traffic

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 1561368
  • - Editorial

Recruitment of Immune Cells into Inflamed Tissues: Consequences for Endothelial Barrier Integrity and Tissue Functionality

Michael Schnoor | Pilar Alcaide | ... | Jaap D. van Buul
  • Special Issue
  • - Volume 2016
  • - Article ID 7650260
  • - Review Article

Cellular Barriers after Extravasation: Leukocyte Interactions with Polarized Epithelia in the Inflamed Tissue

Natalia Reglero-Real | Diego García-Weber | Jaime Millán
  • Special Issue
  • - Volume 2015
  • - Article ID 670248
  • - Clinical Study

Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4

Alexander Lukasz | Jan Beneke | ... | Mario Schiffer
  • Special Issue
  • - Volume 2015
  • - Article ID 418290
  • - Review Article

Tumor-Induced Local and Systemic Impact on Blood Vessel Function

J. Cedervall | A. Dimberg | A-K. Olsson
  • Special Issue
  • - Volume 2015
  • - Article ID 737310
  • - Research Article

Role of Calprotectin as a Modulator of the IL27-Mediated Proinflammatory Effect on Endothelial Cells

Susann A. Dorosz | Aurélien Ginolhac | ... | Jean-Luc Bueb
  • Special Issue
  • - Volume 2015
  • - Article ID 946509
  • - Review Article

Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation

Michael Schnoor | Pilar Alcaide | ... | Jaap D. van Buul
  • Special Issue
  • - Volume 2015
  • - Article ID 652035
  • - Review Article

Leukocytes: The Double-Edged Sword in Fibrosis

Jakub Kryczka | Joanna Boncela
  • Special Issue
  • - Volume 2015
  • - Article ID 197150
  • - Research Article

Early Dynamics of Cerebrospinal CD14+ Monocytes and CD15+ Granulocytes in Patients after Severe Traumatic Brain Injury: A Cohort Study

Lukas Kurt Postl | Viktoria Bogner | ... | Chlodwig Kirchhoff
  • Special Issue
  • - Volume 2015
  • - Article ID 463950
  • - Research Article

Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma

Stephanie Denk | Rebecca Wiegner | ... | Markus Huber-Lang
  • Special Issue
  • - Volume 2015
  • - Article ID 272858
  • - Review Article

Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation

Alejandro Pablo Adam
Mediators of Inflammation
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Acceptance rate35%
Submission to final decision79 days
Acceptance to publication30 days
CiteScore3.570
Impact Factor3.545
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