Mediators of Inflammation

Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2016


Publishing date
21 Oct 2016
Status
Published
Submission deadline
03 Jun 2016

Lead Editor

1University of Sao Paulo, Sao Paulo, Brazil

2Sao Paulo State University, Presidente Prudente, Brazil

3National Institute of Health, Bethesda, USA

4National Institute of Health, Bethesda, USA


Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2016

Description

Chronic nonresolving inflammation is a critical condition found in several highly incident diseases such as obesity, cancer, type 2 diabetes, and atherosclerosis. Despite major implication in disease, the mechanisms underlying the development and failure to resolve such chronic inflammation are still not completely elucidated. Several lines of evidence indicate the existence of a complex interrelationship between inflammatory processes and metabolism. In this sense, changes in metabolism as those found upon overnutrition among other situations were demonstrated to modulate leukocyte function and induce inflammatory processes. Indeed, changes in the activity of the nutrient sensors mTOR and PPARs, for example, are associated with important alterations in inflammatory processes. Conversely, inflammation and inflammatory mediators are associated with major changes in cell and tissue metabolism. For instance, chronic inflammation is associated with an impairment of insulin stimulating glucose uptake and inhibition of lipolysis, in addition to the cross talk between metabolic organs, such as liver, adipose tissue, skeletal muscle, and gastrointestinal tract with immune cells.

In this special issue, we invite investigators to contribute original research and review articles that address the complex interrelationships between immune system and metabolism. We are particularly interested in articles describing novel mechanisms of interaction between nutrients and metabolites, immune function and inflammation, and possible strategies to prevent or treat metabolic diseases.

Potential topics include, but are not limited to:

  • Cell nutrient and energy sensors (G protein-coupled receptors, mTOR, PPARs, AMPK, etc.) as regulators of leukocyte function, immune responses, and inflammation
  • Microbiome and therapies associated with pre- and probiotics in metabolic diseases
  • Modulation of lipid, protein, and carbohydrate metabolism by inflammatory mediators
  • Metabolomics and lipidomics of cells and tissue upon inflammatory conditions

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 8230298
  • - Editorial

Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2016

Jose C. Rosa Neto | Fabio S. Lira | ... | William Festuccia
  • Special Issue
  • - Volume 2016
  • - Article ID 1536047
  • - Research Article

FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids

Simone Isling Pærregaard | Marianne Agerholm | ... | Benjamin Anderschou Holbech Jensen
  • Special Issue
  • - Volume 2016
  • - Article ID 7150509
  • - Research Article

Serum Amyloid A Promotes E-Selectin Expression via Toll-Like Receptor 2 in Human Aortic Endothelial Cells

Eisaku Nishida | Makoto Aino | ... | Akio Mitani
  • Special Issue
  • - Volume 2016
  • - Article ID 9236196
  • - Research Article

Dietary Chitosan Supplementation Increases Microbial Diversity and Attenuates the Severity of Citrobacter rodentium Infection in Mice

Guiping Guan | Hongbing Wang | ... | Jun Fang
  • Special Issue
  • - Volume 2016
  • - Article ID 4036232
  • - Review Article

Multiple Sclerosis and Obesity: Possible Roles of Adipokines

José de Jesús Guerrero-García | Lucrecia Carrera-Quintanar | ... | Daniel Ortuño-Sahagún
  • Special Issue
  • - Volume 2016
  • - Article ID 9142425
  • - Research Article

SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration

Zhen-Zhen Guo | Qun-An Cao | ... | Qiu-Yan Dai
  • Special Issue
  • - Volume 2016
  • - Article ID 9890141
  • - Review Article

Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel Disease

Phillips-Farfán Bryan | Carvajal Karla | ... | Camacho Luz
  • Special Issue
  • - Volume 2016
  • - Article ID 7141430
  • - Research Article

Anti-Inflammatory Effects of Hyperbaric Oxygenation during DSS-Induced Colitis in BALB/c Mice Include Changes in Gene Expression of HIF-1α, Proinflammatory Cytokines, and Antioxidative Enzymes

Sanja Novak | Ines Drenjancevic | ... | Martina Mihalj
  • Special Issue
  • - Volume 2016
  • - Article ID 3957958
  • - Review Article

Inflammatory Mechanisms Associated with Skeletal Muscle Sequelae after Stroke: Role of Physical Exercise

Hélio José Coelho Junior | Bruno Bavaresco Gambassi | ... | Bruno Rodrigues
  • Special Issue
  • - Volume 2016
  • - Article ID 2839232
  • - Research Article

Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17

Wenkai Ren | Shuai Chen | ... | Yulong Yin
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.400
Journal Citation Indicator0.610
Impact Factor4.711
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