Mediators of Inflammation

Anti-inflammatory Natural Products


Publishing date
15 May 2015
Status
Published
Submission deadline
26 Dec 2014

Lead Editor

1Shanghai University of Traditional Chinese Medicine, Shanghai, China

2Immune Disease Institute, Boston, USA

3Joslin Diabetes Center, Boston, USA

4Cincinnati Children’s Hospital Medical Center, Cincinnati, USA


Anti-inflammatory Natural Products

Description

Inflammation is the first biological response of the immune system against infection or irritation. However, accumulating epidemiological and clinical study indicates that zealous acute inflammation or chronic inflammatory reaction is a significant risk factor to develop various human diseases. Controlling or modulating inflammation is therefore important to prevent or ameliorate certain diseases. Various natural products derived from medical herbs have been well characterized to regulate inflammatory diseases, such as astragalus polysaccharides, cannabinoids, berberine, curcumin, triptolide, and some flavonoids. Recent advances in chemistry and biology have introduced new technologies to synthesize or purify components from natural products and also improved the studies of underlying mechanisms of action. Investigations of anti-inflammatory natural products definitely will lead to the development of novel therapeutic agents to provide better care to patients. We are interested in articles that explore the effects and molecular mechanisms of natural products or their derivatives with clear molecular structure (crude extracts are not qualified) in inflammatory diseases.

Potential topics include, but are not limited to:

  • Neutrophil recruitment, infiltration, and activation and formation of extracellular traps (NETs)
  • Monocyte and macrophage activation and related signaling pathways, such as MAPKs, NK-κB, and COX-2
  • Balance between the effector T cell and regulator T cell differentiation, interleukin-17-producing CD4 T cells (Th17), and IL-17-producing innate immune cells such as γδ T cells and neutrophils
  • Molecular events involved in CD8 T cell activation and exhaustion in chronic viral persistence, such as PD-1/PD-L1 expression and downstream signaling pathway
  • TCR-associated CD-3 ζ and ZAP70 and downstream PI3K/mTOR pathway
  • Expression of cytokine and other effector molecules including IFN-γ and CD107a/b

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 608613
  • - Editorial

Anti-Inflammatory Natural Products

Yifu Yang | Lifei Hou | ... | Lijun Xin
  • Special Issue
  • - Volume 2015
  • - Article ID 380218
  • - Research Article

Punicalagin Induces Nrf2/HO-1 Expression via Upregulation of PI3K/AKT Pathway and Inhibits LPS-Induced Oxidative Stress in RAW264.7 Macrophages

Xiaolong Xu | Hongquan Li | ... | Jianqin Xu
  • Special Issue
  • - Volume 2015
  • - Article ID 274314
  • - Research Article

Astragaloside IV Inhibits NF-κB Activation and Inflammatory Gene Expression in LPS-Treated Mice

Wei-Jian Zhang | Balz Frei
  • Special Issue
  • - Volume 2015
  • - Article ID 918089
  • - Research Article

The Combination of N-Acetyl Cysteine, Alpha-Lipoic Acid, and Bromelain Shows High Anti-Inflammatory Properties in Novel In Vivo and In Vitro Models of Endometriosis

C. Agostinis | S. Zorzet | ... | R. Bulla
  • Special Issue
  • - Volume 2015
  • - Article ID 460264
  • - Research Article

Construction, Expression, and Characterization of a Recombinant Immunotoxin Targeting EpCAM

Minghua Lv | Feng Qiu | ... | Kui Zhang
  • Special Issue
  • - Volume 2015
  • - Article ID 435713
  • - Review Article

Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives

Chenchen Shi | Haipeng Li | ... | Lifei Hou
  • Special Issue
  • - Volume 2015
  • - Article ID 626934
  • - Research Article

The Evaluation of Plasma and Leukocytic IL-37 Expression in Early Inflammation in Patients with Acute ST-Segment Elevation Myocardial Infarction after PCI

Xin Wang | Xiangna Cai | ... | Jilin Li
  • Special Issue
  • - Volume 2015
  • - Article ID 419106
  • - Research Article

Ginkgo biloba Extract Improves Insulin Signaling and Attenuates Inflammation in Retroperitoneal Adipose Tissue Depot of Obese Rats

Bruna Kelly Sousa Hirata | Renata Mancini Banin | ... | Monica Marques Telles
  • Special Issue
  • - Volume 2015
  • - Article ID 463530
  • - Research Article

Inhibitory Effect of Methyleugenol on IgE-Mediated Allergic Inflammation in RBL-2H3 Cells

Feng Tang | Feilong Chen | ... | Xiaomei Tan
  • Special Issue
  • - Volume 2015
  • - Article ID 563713
  • - Research Article

Percentages of CD4+CD161+ and CD4−CD8−CD161+ T Cells in the Synovial Fluid Are Correlated with Disease Activity in Rheumatoid Arthritis

Jinlin Miao | Kui Zhang | ... | Ping Zhu
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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