Mediators of Inflammation

Lipid Mediators and the Immune Response


Publishing date
06 Jul 2012
Status
Published
Submission deadline
17 Feb 2012

1School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

2Department of Microbiology and Immunology, University of Michigan Health System, Ann Arbor, USA

3Department of Veterans Affairs, Jesse Brown VA Hospital, Chicago, USA

4Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA

5Faculty of Medicine, Laval University, Quebec, Canada


Lipid Mediators and the Immune Response

Description

Polyunsaturated fatty acids (PUFAs) are metabolized into mediators that exhibit various biological effects. Lipid mediators derived from the omega-6 PUFA arachidonic acid (AA) include leukotrienes (LTs), prostaglandins (PGs), and lipoxins. These mediators are involved in the regulation of many inflammatory disorders. They are synthesized by most leukocytes and stromal cells and released in response to numerous stimuli including microbes, opsonins, pollutants, cytokines, venoms, immune complexes, and danger signals. LTs are classically known for their chemotactic/chemokinetic properties (LTB4) and their bronchoconstrictive activities (cysLTs), but they are also potent mediators of innate and adaptive immunity. LTs promote phagocyte recruitment and activation, as well as antigen presentation by enhancing dendritic cell and T cell responses. Conversely, PGD2, PGE2, and PGI2 display an interesting array of pro- and anti-inflammatory signals that modulate inflammatory responses and host defense. Other AA-derived mediators such as epoxy-eicosanoids, eoxins, lipoxins, hydroxy-eicosanoids and endocannabioids are established and/or emerging immunomodulators. Mediators derived from omega-3 PUFAs include resolvins, protectins and docosatrienes. These present wide-ranging anti-inflammatory and pro-resolution properties that are attributed to inhibition of inflammatory cytokine production; suppression of pro-inflammatory gene and cell adhesion molecule expression; down-regulation of nuclear transcription factor activation; and to induction of inflammatory cell apoptosis and phagocytosis. These events might protect tissues from damage and induce clearance of inflammatory cellular debris, promoting the resolution of inflammation and a return to homeostasis.

In this special issue of Mediators of Inflammation, we are seeking manuscripts highlighting novel aspects of lipids as immunomodulators. We aim to cover key and current trends in immunomodulatory lipids. Review articles that underscore and discuss conflicting or controversial results are welcome. Potential topics include, but are not limited to:

  • Biosynthesis and metabolism
  • Involvement of lipids in infectious and chronic diseases
  • Lipids as mediators of tissue fibrosis and repair
  • Regulation and control of innate and adaptive immunity
  • Lipid mediators as promising targets for therapeutics

These aspects are important to understand the roles of lipid mediators in animal and human pathophysiology.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 327568
  • - Review Article

Prostaglandin E 𝟐 and the Suppression of Phagocyte Innate Immune Responses in Different Organs

Alexandra Medeiros | Camila Peres-Buzalaf | ... | C. Henrique Serezani
  • Special Issue
  • - Volume 2012
  • - Article ID 926968
  • - Review Article

PGI2 as a Regulator of Inflammatory Diseases

Stacy L. Dorris | R. Stokes Peebles
  • Special Issue
  • - Volume 2012
  • - Article ID 503128
  • - Review Article

PGD Synthase and PGD2 in Immune Resposne

Myungsoo Joo | Ruxana T. Sadikot
  • Special Issue
  • - Volume 2012
  • - Article ID 946813
  • - Review Article

Role of Prostaglandins in Neuroinflammatory and Neurodegenerative Diseases

Isabel Vieira de Assis Lima | Leandro Francisco Silva Bastos | ... | Antonio Carlos Pinheiro de Oliveira
  • Special Issue
  • - Volume 2012
  • - Article ID 236345
  • - Review Article

Eicosanoids and Respiratory Viral Infection: Coordinators of Inflammation and Potential Therapeutic Targets

Mary K. McCarthy | Jason B. Weinberg
  • Special Issue
  • - Volume 2012
  • - Article ID 696897
  • - Review Article

Cyclooxygenase Inhibition in Sepsis: Is There Life after Death?

David M. Aronoff
  • Special Issue
  • - Volume 2012
  • - Article ID 320953
  • - Research Article

oxLDL Downregulates the Dendritic Cell Homing Factors CCR7 and CCL21

Thomas Nickel | Susanne Pfeiler | ... | Michael Weis
  • Special Issue
  • - Volume 2012
  • - Article ID 478601
  • - Review Article

Lipid Bodies: Inflammatory Organelles Implicated in Host-Trypanosoma cruzi Interplay during Innate Immune Responses

Heloisa D'Avila | Daniel A. M. Toledo | Rossana C. N. Melo
  • Special Issue
  • - Volume 2012
  • - Article ID 837375
  • - Research Article

Pregnancy Followed by Delivery May Affect Circulating Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels in Women of Reproductive Age

Mehmet Balin | Ahmet Çelik | ... | Adil Baydas
  • Special Issue
  • - Volume 2012
  • - Article ID 595694
  • - Review Article

Role of Leukotrienes on Protozoan and Helminth Infections

Alexandre P. Rogerio | Fernanda F. Anibal
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision79 days
Acceptance to publication36 days
CiteScore3.570
Impact Factor3.545
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