Mediators of Inflammation

Mediators of Inflammation in Myeloproliferative Neoplasms: State of the Art


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Published

Lead Editor

1Université de Nantes, Nantes, France

2University of Copenhagen, Copenhagen, Denmark

3University of Belgrade, Belgrade, Serbia


Mediators of Inflammation in Myeloproliferative Neoplasms: State of the Art

Description

Myeloproliferative neoplasms (MPNs) are heterogeneous group of chronic clonal diseases characterized by the excessive production of mature cells of one or more of the myeloid lineages. Recent advances in the biology of MPNs have greatly facilitated their molecular diagnosis, since almost all MPN patients present with mutation in the JAK2, MPL, or CALR genes. Yet the precise role of these mutations in the pathogenesis of the different subtypes of MPNs is not elucidated. Moreover, complications range from mild clinical symptoms such as itching or weight loss to thrombotic events, fibrosis of the bone marrow, splenomegaly, and acute myeloid leukemia. Some of these complications can be linked to the chronic inflammation associated with MPN disease, and the JAK inhibitor clinical trials showed that the reduction of symptoms linked to inflammation was beneficial to patients. Moreover, there is evidence that, for subsets of MPN patients, inflammation may be independent from or/and precede acquisition of mutations in JAK2, MPL, or CALR genes. Thus, better understanding of the causes and molecular mechanisms that underlie chronic inflammation in MPNs seems necessary to improve the treatments currently proposed to MPN patients. To achieve this aim, we propose a new analysis, focusing on inflammation, of the large body of data accumulated in MPNs over the past ten years. This new approach will bring new insights in the pathophysiology of MPNs and highlight new approaches for the therapy of these diseases.

Therefore we invite investigators to contribute original research articles and review articles that will describe, analyze, or summarize the biological and clinical findings accumulated with regard to inflammation in MPNs, with the aim of reaching consensus on the main cytokines and molecular mechanisms that underlie inflammation in MPNs. Then novel therapeutic strategies that target inflammation in addition to the main MPN mutations will be discussed. Note that, here, the term ''inflammatory'' refers to both pro- and anti-inflammatory cytokines, and the chemokines may be included in the cytokine family.

Potential topics include, but are not limited to:

  • The important inflammatory cytokines/chemokines deregulated in MPNs, as possible predictive markers of disease severity
  • Inflammatory cytokines/chemokines as “fuel” for clonal MPN progenitor cell growth
  • Inflammatory cytokines/chemokines as drivers of MPN mutations
  • Murine model systems for MPNs–emphasizing the role of inflammation
  • Congenital genetic factors influencing inflammation in MPNs in humans
  • Epigenetic regulation of inflammatory cytokine/chemokine expression or signaling
  • Inflammation and increased risk of thrombosis in MPNs
  • Inflammation and myelofibrosis in MPNs
  • Inflammatory markers as predictors of complication in MPNs
  • Possible nongenetic causes of inflammation in MPNs
  • Effects of current drugs or combinations of drugs acting on inflammation in MPNs
  • Novel therapeutic strategies targeting inflammation in MPNs

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 964613
  • - Editorial

Mediators of Inflammation in Myeloproliferative Neoplasms: State of the Art

Sylvie Hermouet | Hans C. Hasselbalch | Vladan Čokić
  • Special Issue
  • - Volume 2015
  • - Article ID 415024
  • - Review Article

Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis

Christophe Desterke | Christophe Martinaud | ... | Marie-Caroline Le Bousse-Kerdilès
  • Special Issue
  • - Volume 2015
  • - Article ID 102476
  • - Review Article

MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives

Hans Carl Hasselbalch | Mads Emil Bjørn
  • Special Issue
  • - Volume 2015
  • - Article ID 970242
  • - Review Article

HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms

Margaux Sevin | François Girodon | ... | Aurélie de Thonel
  • Special Issue
  • - Volume 2015
  • - Article ID 101987
  • - Research Article

The Hen or the Egg: Inflammatory Aspects of Murine MPN Models

Jonas S. Jutzi | Heike L. Pahl
  • Special Issue
  • - Volume 2015
  • - Article ID 869242
  • - Review Article

Cytokine Regulation of Microenvironmental Cells in Myeloproliferative Neoplasms

Gregor Hoermann | Georg Greiner | Peter Valent
  • Special Issue
  • - Volume 2015
  • - Article ID 284706
  • - Review Article

Impact of Inflammation on Myeloproliferative Neoplasm Symptom Development

Holly L. Geyer | Amylou C. Dueck | ... | Ruben A. Mesa
  • Special Issue
  • - Volume 2015
  • - Article ID 606819
  • - Review Article

Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm

Angela G. Fleischman
  • Special Issue
  • - Volume 2015
  • - Article ID 648090
  • - Review Article

The Role of Reactive Oxygen Species in Myelofibrosis and Related Neoplasms

Mads Emil Bjørn | Hans Carl Hasselbalch
  • Special Issue
  • - Volume 2015
  • - Article ID 145293
  • - Review Article

Pathogenesis of Myeloproliferative Neoplasms: Role and Mechanisms of Chronic Inflammation

Sylvie Hermouet | Edith Bigot-Corbel | Betty Gardie
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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