Mediators of Inflammation

Inflammation in Cachexia


Status
Published

1University of São Paulo, São Paulo, Brazil

2University of Rome, Rome, Italy

3University of Barcelona, Barcelona, Spain

4University of Potsdam, Potsdam, Germany

5University of Mogi das Cruzes, São Paulo, Brazil


Inflammation in Cachexia

Description

Cachexia is a devastating wasting syndrome that is associated with various diseases, being highly prevalent in cancer (80% in advanced disease) and representing the direct cause of death of up to 40% of the patients. The most common symptoms are severe depletion of fat and muscle mass, anorexia, fatigue, endocrine and metabolic chaos, and chronic systemic inflammation. Morbimortality is enhanced, and the results of therapy are compromised. Despite its unequivocal importance in the clinical setting, the syndrome is frequently underdiagnosed and seldom treated. There is no single therapy known to be able to counteract this plethora of symptoms and the aetiology of cachexia remains not fully elucidated. Nevertheless, the concept that chronic systemic inflammation underlies the alterations that lead in concert to wasting is acquiring vigour among scientists. Many authors thus consider this symptom a hallmark of cachexia, and when scoring the syndrome, circulating levels of C-reactive protein and proinflammatory interleukins are considered.

The purpose of the special issue is to contemplate the relevance of inflammation to the aetiology of cachexia, to address the mechanisms triggering the onset of the inflammatory state, and to evaluate the potential of inflammation-related markers for the diagnosis of the syndrome. Strategies aiming at counteracting systemic inflammation in cachexia shall be also discussed.

We invite investigators to contribute original research articles and reviews.

Potential topics include, but are not limited to:

  • Inflammatory and noninflammatory markers in cachexia diagnosis and staging
  • Tissue and organ inflammation in cachexia
  • Immune system in cachexia
  • Mediators in cachexia:
    • Cytokines
    • Eicosanoids and lipid mediators
    • Cellular markers
    • ROS adipokines and metabolites
  • Central nervous system inflammation and anorexia in cachexia
  • Strategies to counteract systemic inflammation in cachexia
  • Microbiota and inflammation in cachexia
  • Tissue cross-talk in cachexia
  • Common mechanisms in systemic inflammation in obesity and cachexia: do they mirror each other?

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 536954
  • - Editorial

Inflammation in Cachexia

M. Seelaender | A. Laviano | ... | M. L. Batista
  • Special Issue
  • - Volume 2015
  • - Article ID 182872
  • - Review Article

Nonmuscle Tissues Contribution to Cancer Cachexia

Josep M. Argilés | Britta Stemmler | ... | Silvia Busquets
  • Special Issue
  • - Volume 2015
  • - Article ID 791060
  • - Review Article

Cancer as a Proinflammatory Environment: Metastasis and Cachexia

Nelson Inácio Pinto | June Carnier | ... | Claudia M. Nascimento
  • Special Issue
  • - Volume 2015
  • - Article ID 805172
  • - Review Article

Role of Inflammation in Muscle Homeostasis and Myogenesis

Domiziana Costamagna | Paola Costelli | ... | Fabio Penna
  • Special Issue
  • - Volume 2015
  • - Article ID 820934
  • - Review Article

Potential Biomarkers of Fat Loss as a Feature of Cancer Cachexia

Maryam Ebadi | Vera C. Mazurak
  • Special Issue
  • - Volume 2015
  • - Article ID 801685
  • - Review Article

Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia

Alessio Molfino | Gianfranco Gioia | ... | Alessandro Laviano
  • Special Issue
  • - Volume 2015
  • - Article ID 367561
  • - Review Article

Cancer Cachexia and MicroRNAs

Rodolfo Gonzalez Camargo | Henrique Quintas Teixeira Ribeiro | ... | Marília Seelaender
  • Special Issue
  • - Volume 2015
  • - Article ID 842070
  • - Research Article

A Survey of Attitudes towards the Clinical Application of Systemic Inflammation Based Prognostic Scores in Cancer

David G. Watt | Campbell S. Roxburgh | ... | Donald C. McMillan
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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