Mediators of Inflammation

Cellular Senescence and Inflammaging in Age-Related Diseases


Status
Published

1University of Palermo, Palermo, Italy

2Università Politecnica delle Marche, Ancona, Italy

3University of Natural Resources and Life Sciences, Vienna, Austria

4Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain


Cellular Senescence and Inflammaging in Age-Related Diseases

Description

The connection between cellular senescence and inflammaging has recently emerged as a causal mechanism of ageing process. This interplay constitutes the favourable substrate for the development of all age-related diseases (ARDs), including cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), musculoskeletal disorders, various types of cancer, and neurodegenerative diseases.

The growing evidence suggests that senescent cells can exert a proinflammaging effect when the rate of accumulation increases, that is, during aging. Upon ageing, they, indeed, acquire a proinflammatory secretory phenotype (SASP), which contributes to spreading inflammaging at the systemic level. In turn, this feeds to a vicious circle that accelerates both tissue dysfunction and onset of all ARDs. Accordingly, SASP of senescent cells has been suggested to contribute to onset of CVDs, insulin resistance, T2DM, and osteoporosis and to senescence of adult stem/progenitor (ASC/APC) cells (i.e., hematopoietic stem cells) associated with tissue dysfunction, immunosenescence, hematologic malignancies, and anaemia. SASP can also stimulate development and progression of several forms of cancer. However, the characterization of SASP components released by different types of senescent cells is not yet complete, as well as the biological functions of various secretomes associated with senescence in different tissue microenvironments.

Although cellular senescence occurs chronically during “normal” ageing, unhealthy lifestyle choices, such as smoking, nonregular exercise, sucrose and/or fat rich diets, and exposure to external stressors (e.g., radiations, pollutants, and chemotherapy), can accelerate the accumulation of senescent cells, therefore promoting onset of ARDs.

Recently, there is increasing evidence that the clearance of senescent cells in animal models attenuates the progression of age-related disorders. This is leading strongly to supporting the hypothesis that senescent cell clearance, reprogramming of senescent cells (epigenetic modulation), or the modulation of proinflammatory pathways related to the acquisition of SASP (i.e., NLRP3 inflammasome, TLR-2/-4, Notch, NF-Kb pathway, insulin/IGF-pathways, and mTOR) may be pursued as potential strategies for combating ARDs and expanding the health span of humans.

The purpose of this special issue is to publish high-quality research papers as well as review articles addressing recent advances in this field. Original, high-quality contributions that are not yet published or that are not currently under review by other journals or peer-reviewed conferences are sought.

Potential topics include but are not limited to the following:

  • Senescence of adult stem/progenitor cells and related mechanisms: inflammaging of niches and effects
  • Senescence of normal cells (including endothelial cells, immune cells, fibroblasts, and preadipocytes) and related biological effects, that is, onset of CVDs, T2DM, musculoskeletal disorders, various types of cancer, and neurodegenerative diseases
  • Mechanisms and pathways related to SASP and inflammaging evocation in different microenvironments
  • Inflammatory markers related to cellular senescence and their diagnostic/prognostic relevance in human ARDs
  • Strategies and interventions to improve the clearance of senescent cells and/or to reduce the systemic spreading of SASP
  • Futuristic clinical settings appropriate to test new senescence or SASP-inflammaging modifying drugs in humans

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 9076485
  • - Editorial

Cellular Senescence and Inflammaging in Age-Related Diseases

Fabiola Olivieri | Francesco Prattichizzo | ... | Carmela R. Balistreri
  • Special Issue
  • - Volume 2018
  • - Article ID 6039171
  • - Review Article

The Role of Immunosenescence in Neurodegenerative Diseases

Erica Costantini | Chiara D’Angelo | Marcella Reale
  • Special Issue
  • - Volume 2018
  • - Article ID 7109312
  • - Research Article

Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring

Federico Sizzano | Sebastiano Collino | ... | Alessio Palini
  • Special Issue
  • - Volume 2018
  • - Article ID 4159013
  • - Review Article

Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy

Marco Malavolta | Massimo Bracci | ... | Mauro Provinciali
  • Special Issue
  • - Volume 2018
  • - Article ID 3705389
  • - Review Article

Anti-Inflamm-Ageing and/or Anti-Age-Related Disease Emerging Treatments: A Historical Alchemy or Revolutionary Effective Procedures?

Carmela Rita Balistreri
  • Special Issue
  • - Volume 2017
  • - Article ID 2309034
  • - Review Article

Mitochondrial (Dys) Function in Inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells?

Angelica Giuliani | Francesco Prattichizzo | ... | Maria Rita Rippo
  • Special Issue
  • - Volume 2017
  • - Article ID 3868545
  • - Research Article

Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals

Costarelli Laura | Giacconi Robertina | ... | Marco Malavolta
  • Special Issue
  • - Volume 2017
  • - Article ID 8102170
  • - Research Article

Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase

Giovanna Traina | Samuela Cataldi | ... | Elisabetta Albi
  • Special Issue
  • - Volume 2017
  • - Article ID 6825493
  • - Review Article

HIV as a Cause of Immune Activation and Immunosenescence

T. Sokoya | H. C. Steel | ... | T. M. Rossouw
  • Special Issue
  • - Volume 2017
  • - Article ID 7953486
  • - Review Article

The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine

Laura Iop | Eleonora Dal Sasso | ... | Giacomo Frati
Mediators of Inflammation
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Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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