Mediators of Inflammation

Cytokines and Chemokines: Disease Models, Mechanisms, and Therapies


Publishing date
27 Dec 2013
Status
Published
Submission deadline
09 Aug 2013

1University of Toledo, USA

2University of Michigan Medical School, USA

3University of Alabama School of Medicine, USA

4Case Western Reserve University School of Medicine, USA


Cytokines and Chemokines: Disease Models, Mechanisms, and Therapies

Description

Recent advances in our understanding of the immunological processes underlying numerous pathologies characterized by elevated levels of proinflammatory and anti‐inflammatory cytokines and chemokines have shaped the current approach to development of novel therapeutics for chronic inflammatory disorders. These evolving concepts in cytokine biology have progressed dramatically with the discovery of chemokines and their receptors as an integral component and regulator of inflammation, which have led to a better understanding of the roles these cytokines and chemokines play in orchestrating a variety of rheumatic, skin, vascular, and infectious diseases. At the same time, these findings have set the stage for successful testing and development of biological therapies in the current treatment regimens for many of these inflammatory diseases. Nonetheless, significant gaps remain in our understanding of how these cytokines and chemokines work, which is partly why some of these novel therapies are not completely effective. This demands that further research be performed aimed to test novel insights into the existing mechanisms of the established inflammatory mediators and discovering the possible role of silent or new players in the phenomenon of acute or chronic inflammation.

This special issue invites investigators to contribute to this area of research in the form of original research articles or reviews that will further strengthen the efforts to understand the cellular and molecular mechanisms of cytokine and chemokine‐mediated inflammation in disease pathogenesis. We are particularly interested in papers that provide novel understanding of the role of cytokines, chemokines, or their receptors in disease pathogenesis and testing of therapeutic strategies in cell/tissue culture systems, animal models, or in the clinical evaluation of inflammatory diseases. Potential topics include, but are not limited to:

  • Identifying new cellular and molecular mechanisms of inflammation involved in the pathogenesis of chronic inflammatory diseases of rheumatic, skin, or vascular tissues
  • Development and testing of new models for human diseases induced by the administration of cytokine/chemokine to understand disease pathogenesis and the benefit of cytokine/chemokine blockade in the amelioration of disease
  • Providing insights into defining novel drug targets for suppression of cytokine/chemokine mediated inflammation using microRNAs, siRNA, and other tools of proteomics
  • Testing of new small molecule inhibitors for the amelioration of inflammation in preclinical in vitro systems and animal models of disease

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/mi/cytok/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 296356
  • - Editorial

Cytokines and Chemokines: Disease Models, Mechanisms, and Therapies

Salahuddin Ahmed | Charles J. Malemud | ... | Dennis D. Taub
  • Special Issue
  • - Volume 2014
  • - Article ID 513027
  • - Erratum

Erratum to “Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1β, and Tumor Necrosis Factor-α via a NF- B-Dependent Mechanism in HaCaT Keratinocytes”

Bing-rong Zhou | Jia-an Zhang | ... | Dan Luo
  • Special Issue
  • - Volume 2014
  • - Article ID 185150
  • - Review Article

The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines

Stefan Landgraeber | Marcus Jäger | ... | Nadim James Hallab
  • Special Issue
  • - Volume 2014
  • - Article ID 136463
  • - Research Article

Effect of Tumor Necrosis Factor Family Member LIGHT (TNFSF14) on the Activation of Basophils and Eosinophils Interacting with Bronchial Epithelial Cells

Huai Na Qiu | Chun Kwok Wong | ... | Zhe Cai
  • Special Issue
  • - Volume 2014
  • - Article ID 703653
  • - Research Article

Monocyte Subsets in Schistosomiasis Patients with Periportal Fibrosis

Jamille Souza Fernandes | Maria Ilma Araujo | ... | Luciana Santos Cardoso
  • Special Issue
  • - Volume 2014
  • - Article ID 746415
  • - Research Article

The Proinflammatory Cytokine High-Mobility Group Box-1 Mediates Retinal Neuropathy Induced by Diabetes

Ahmed M. Abu El-Asrar | Mohammad Mairaj Siddiquei | ... | Ghulam Mohammad
  • Special Issue
  • - Volume 2014
  • - Article ID 590409
  • - Research Article

Interactions between Neutrophils, Th17 Cells, and Chemokines during the Initiation of Experimental Model of Multiple Sclerosis

Dagmara Weronika Wojkowska | Piotr Szpakowski | ... | Andrzej Glabinski
  • Special Issue
  • - Volume 2014
  • - Article ID 590654
  • - Research Article

Regulation of Chemokine CCL5 Synthesis in Human Peritoneal Fibroblasts: A Key Role of IFN-γ

Edyta Kawka | Janusz Witowski | ... | Achim Jörres
  • Special Issue
  • - Volume 2014
  • - Article ID 659206
  • - Review Article

Chemokines and Chemokine Receptors in Multiple Sclerosis

Wenjing Cheng | Guangjie Chen
  • Special Issue
  • - Volume 2014
  • - Article ID 292376
  • - Review Article

The Inflammatory Chemokine CCL5 and Cancer Progression

Donatella Aldinucci | Alfonso Colombatti
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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