Mediators of Inflammation

Regulation of Inflammation in Myocardial Ischemia-Reperfusion


Publishing date
01 Jan 2020
Status
Closed
Submission deadline
30 Aug 2019

1University of Verona, Verona, Italy

2Medical University of Vienna, Vienna, Austria

This issue is now closed for submissions.
More articles will be published in the near future.

Regulation of Inflammation in Myocardial Ischemia-Reperfusion

This issue is now closed for submissions.
More articles will be published in the near future.

Description

In the last decade inflammation has been recognized as playing an important role following ischemia-reperfusion injury and, as a consequence, to be an important therapeutic target for the treatment of heart failure. However, inflammation contributes differently to the pathogenesis of cardiac dysfunction and to different patterns of cardiac remodeling. Several mediators of inflammation trigger the remodeling cascade, a process that initially confers protection to the heart as a compensatory mechanism. Yet chronic inflammation after myocardial infarction also leads to cardiac remodeling that, when prolonged, leads to heart failure progression.

The diversity of inflammation further demonstrates the need for a tailored characterization of inflammation enabling subsequent target-specific strategies. This necessity is supported by the disappointing results to date of anti-inflammatory strategies used in heart failure patients.

This special issue is designed to focus on the interplay of inflammation and cell injury/death following myocardial ischemia-reperfusion. The issue also aims to investigate the impact of regulation of inflammatory signals on the evolution of cardiac remodeling and function and to identify novel potential therapeutic targets. Both basic science and clinical studies are welcomed.

Potential topics include but are not limited to the following:

  • Characteristics and mechanisms of myocardial ischemia-reperfusion injury
  • Mediators, pathways, and markers of inflammation in myocardial ischemia-reperfusion
  • Cell injury and cell death and their role in inflammation following myocardial ischemia-reperfusion
  • Kinetics of inflammatory response and repair in myocardial ischemia-reperfusion
  • Oxidative stress and inflammation in myocardial ischemia-reperfusion
  • Kinetics of interventions and their role in short and long-term remodeling
  • Potential therapeutic targets to modulate inflammation following myocardial ischemia-reperfusion

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 6079713
  • - Research Article

The Prognostic Impact of Circulating Regulatory T Lymphocytes on Mortality in Patients with Ischemic Heart Failure with Reduced Ejection Fraction

Andreas Hammer | Patrick Sulzgruber | ... | Alexander Niessner
  • Special Issue
  • - Volume 2020
  • - Article ID 8405370
  • - Review Article

Ischemia/Reperfusion Injury: Pathophysiology, Current Clinical Management, and Potential Preventive Approaches

César Daniel Sánchez-Hernández | Lucero Aidé Torres-Alarcón | ... | Alberto N. Peón
  • Special Issue
  • - Volume 2020
  • - Article ID 5141503
  • - Research Article

Analysis of Myocardial Ischemia Parameters after Coronary Artery Bypass Grafting with Minimal Extracorporeal Circulation and a Novel Microplegia versus Off-Pump Coronary Artery Bypass Grafting

Luca Koechlin | Urs Zenklusen | ... | Oliver Reuthebuch
  • Special Issue
  • - Volume 2019
  • - Article ID 5648051
  • - Research Article

Bretschneider (Custodiol®) and St. Thomas 2 Cardioplegia Solution in Mitral Valve Repair via Anterolateral Right Thoracotomy: A Propensity-Modelled Comparison

Constantin Mork | Luca Koechlin | ... | Martin T. R. Grapow
  • Special Issue
  • - Volume 2019
  • - Article ID 6431957
  • - Research Article

Post-TTM Rebound Pyrexia after Ischemia-Reperfusion Injury Results in Sterile Inflammation and Apoptosis in Cardiomyocytes

Giang Tong | Nalina N. A. von Garlen | ... | Katharina R. L. Schmitt
  • Special Issue
  • - Volume 2019
  • - Article ID 7816491
  • - Research Article

Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI

Ragnhild Helseth | Christian Shetelig | ... | Ingebjørg Seljeflot
  • Special Issue
  • - Volume 2019
  • - Article ID 7583760
  • - Research Article

Enhanced Activity by NKCC1 and Slc26a6 Mediates Acidic pH and Cl Movement after Cardioplegia-Induced Arrest of db/db Diabetic Heart

Minjeong Ji | Seok In Lee | ... | Jeong Hee Hong
Mediators of Inflammation
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Acceptance rate36%
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