The inflammatory response is activated during ischaemia-reperfusion, which contributes to the development of ischaemia-reperfusion injury. Timely inhibition and reduction of inflammation is essential for rescuing ischaemic tissues and organs from ischemia-reperfusion injury.

Inflammatory resolution is a process characterised by neutrophil apoptosis, macrophage-mediated clearance of apoptotic neutrophils, decreased production of inflammatory mediators, and increased production of specialised pro-resolving mediators (SPM). Inflammatory resolution mechanisms are activated during ischaemia-reperfusion and have been shown to be protective against ischaemia-reperfusion injury. Moreover, exogenous SPMs such as lipoxins, resolvins, protectins, and maresins have been identified as potential therapeutics in ischaemia-reperfusion injury. However, the molecular mechanisms of inflammatory resolution and the therapeutic effect of SPMs in ischaemia-reperfusion injury are unclear.

The aim of this Special Issue is to collate original research articles as well as review articles that will stimulate continuing efforts to understand these molecular mechanisms. Knowledge of the role of inflammatory resolution and the effect of SPMs (such as lipoxins, resolvins, protectins, and maresins) in ischaemia-reperfusion injury under normal and diseased conditions will help to develop strategies to combat these pathological conditions.

Potential topics include but are not limited to the following:

• The role and mechanism of inflammatory resolution in ischaemia-reperfusion injury in different organs, for example, heart, lung, brain, liver, kidney, and intestine under normal and diseased conditions, such as diabetes and ageing
• The role and mechanism of different SPMs (e.g., lipoxins, resolvins, protectins, and maresins) in ischaemia-reperfusion injury under normal and diseased conditions
• Studies exploring the molecular mechanisms associated to SPMs and their protective role in vitro
• Clinical studies focused on inflammatory resolution in diseases related to ischaemia-reperfusion injury
• Recent advances in preventing ischaemia-reperfusion injury with a focus on inflammatory resolution