Mediators of Inflammation

Periodontal Disease and Its Systemic Associated Diseases


Status
Published

1University of Buenos Aires, Buenos Aires, Argentina

2Experimental Medical Institute (Medical National Academy-CONICET), Buenos Aires, Argentina

3The Australian National University, Canberra, Australia


Periodontal Disease and Its Systemic Associated Diseases

Description

Periodontitis is an oral disease comprising a group of inflammatory conditions affecting dentition supporting structures, including the periodontal ligament, alveolar bone, and gingival tissues. The host response plays a critical role in periodontal tissue breakdown. Whereas the activity of periodontal pathogens is required, their presence is not sufficient to account for the initiation and progression of periodontal disease. Lipopolysaccharide, a key component of the outer membrane of Gram-negative bacteria, stimulates host cells to produce a number of proinflammatory cytokines such as tumor necrosis factor alpha, interleukin-1, and interleukin-6. It also stimulates the production of other inflammatory mediators, such as prostaglandin E2 and nitric oxide. This inflammatory cascade promotes metalloproteinase matrix release from host tissues and causes deleterious effects in the extracellular matrix and alveolar bone. Periodontitis starts as a local infection, but the triggering of a chronic inflammatory cascade increases the susceptibility to acquire infectious diseases and other serious pathological conditions such as cardiovascular disease, mental disorders (e.g., depression), and diabetes. Additionally, frequent environmental exposure to stress, smoking, alcoholism, and drugs of abuse predispose the host to acquire and/or exacerbate the deleterious effects of periodontal disease. Therefore, the present issue attempts to discuss new approaches to prevent and treat periodontitis and its deleterious side effects.

In summary, a local inflammatory process, like the one that takes place during the early stage of periodontal disease, can reach a systemic dimension affecting the etiology of several other pathological conditions including the ones mentioned above. Therefore, we invite investigators to contribute original research and review articles to expand the understanding of periodontitis, a chronic infectious/inflammatory process that can alter the homeostasis of the whole organism in a severe manner.

Potential topics include, but are not limited to:

  • Epidemiology of periodontal diseases: incidence, prevalence, geographical distribution, and comorbidities
  • Risk factors for periodontitis
  • Periodontitis and cardiovascular disease
  • Periodontitis and systemic infectious diseases
  • Periodontitis and diabetes
  • Stress, mental disorders and periodontitis
  • Periodontitis and tuberculosis

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 379626
  • - Review Article

Periodontal Diseases and Dental Caries in Children with Type 1 Diabetes Mellitus

Marta Novotna | Stepan Podzimek | ... | Jana Duskova
  • Special Issue
  • - Volume 2015
  • - Article ID 564858
  • - Research Article

C-Reactive Protein in Peripheral Blood of Patients with Chronic and Aggressive Periodontitis, Gingivitis, and Gingival Recessions

Stepan Podzimek | Jaroslav Mysak | ... | Jana Duskova
  • Special Issue
  • - Volume 2015
  • - Article ID 259074
  • - Review Article

Relationship between Periodontitis and Rheumatoid Arthritis: Review of the Literature

Vilana Maria Adriano Araújo | Iracema Matos Melo | Vilma Lima
  • Special Issue
  • - Volume 2015
  • - Article ID 153074
  • - Editorial

Periodontal Disease and Its Systemic Associated Diseases

Javier Fernandez-Solari | Paula Barrionuevo | Claudio A. Mastronardi
  • Special Issue
  • - Volume 2015
  • - Article ID 481656
  • - Research Article

HLA Haplotypes and Genotypes Frequencies in Brazilian Chronic Periodontitis Patients

Emília Ângela Sippert | Cléverson de Oliveira e Silva | ... | Ana Maria Sell
  • Special Issue
  • - Volume 2015
  • - Article ID 548540
  • - Review Article

Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review

D. C. B. Cortela | A. L. de Souza Junior | ... | E. Ignotti
  • Special Issue
  • - Volume 2015
  • - Article ID 147056
  • - Research Article

The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients

Joana Maira Valentini Zacarias | Emília Ângela Sippert | ... | Ana Maria Sell
  • Special Issue
  • - Volume 2015
  • - Article ID 793898
  • - Review Article

The Two-Way Association of Periodontal Infection with Systemic Disorders: An Overview

Ravinder Nagpal | Yuichiro Yamashiro | Yuichi Izumi
Mediators of Inflammation
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Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.400
Impact Factor4.711
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