Mediators of macrophage-induced inflammation are critical for a variety of human inflammatory disorders, such as sepsis-related multiple organ dysfunction/multiple organ failure, microbial infection, acute brain, lung, hepatic, renal injuries, neurodegenerative disorders, tumorigenesis, osteoporosis/osteonecrosis, cardiovascular and metabolic diseases, and autoimmune diseases. Most of these cases are proinflammatory and pathogenic for disease progression once the activated macrophages actively secrete and cause an imbalance of cytokines, chemokines, and inflammation mediators. For inflammation resolution, anti-inflammatory cytokines such as interleukin-10 and transforming growth factor-β are also regulated for macrophage activation to repair the inflammatory insults. In addition to secreting mediators of inflammation, macrophage-mediated phagocytosis is generally involved not only for inflammation but also anti-inflammation.

The primary focus of this special issue will be on the current and updated knowledge of macrophage-mediated inflammatory disorders, particularly on the pathogenesis of the macrophage activation, mediators of inflammation and anti-inflammation, and strategies against such effects. In this special issue, both reviews and original research articles are welcomed. Moreover, papers showing novel methods for detecting macrophage activation and differentiation would be of great interest. Potential topics include, but are not limited to:

• Macrophages in infection and immunity
• Macrophages in acute brain, lung, hepatic, renal injuries, and autoimmunity
• Macrophage/microglia in neurodegenerative disorders
• Tumor-associated macrophages in tumorigenesis
• Macrophages in inflammatory/autoimmune musculoskeletal diseases
• Macrophages in cardiovascular disorders and metabolic diseases

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: