Mediators of Inflammation

Mediators of Gut Mucosal Immunity and Inflammation


Status
Published

1Department of Immunology, School of Medicine, Bulent Ecevit University, Zonguldak, Turkey

2Department of Immunology, School of Medicine, Uludag University, Bursa, Turkey

3Department of Genetics and Cell-Biology, Maastricht University Medical Centre, Maastricht, The Netherlands


Mediators of Gut Mucosal Immunity and Inflammation

Description

The gastrointestinal tract is continuously exposed to foreign antigens such as derived from food and microbiota of gut. Gut flora is an important entity of human body that plays crucial role in healthy immune system and various immunological disorders. Exploration of interactions between gut flora and immune system is an important area of current investigations.

The first view of the mucosal immune systems is a single-layer epithelium covered by mucus and antimicrobial products and fortified by both innate and adaptive components of host defense. The migration of immune cells from mucosal inductive to effector tissues via the lymphatic system is the cellular basis for the immune response in the gastrointestinal system.

Cytokines and chemokines are an integral component of the adaptive and innate immune response in the gastrointestinal system. Cytokines are involved in a variety of immunological, inflammatory and infectious diseases. Chemokines are a family of small cytokines or proteins secreted by numerous cells. The major role of chemokines is to guide the migration of particular cells. The mediators of gut mucosal immunity and inflammation are not limited to chemokines and cytokines. There are many inflammatory and anti-inflammatory molecules derived from gut mucosal endothelial cells and leucocytes.

We invite researchers to contribute to this special issue in the form of original research articles or reviews that will further strengthen the efforts to understand the cellular and molecular mechanisms of mediators in gut immunity and inflammation. Also, we are waiting for clinical studies about our potential topics. Potential topics include, but are not limited to:

  • The importance of cytokines and chemokines in intestinal immune system and gut microbiota
  • Relationship between cytokines, chemokines, and gut microbiota in gastrointestinal inflammation
  • The immunomodulatory properties of commensal bacteria in the gut
  • Host cell cytokine and chemokine responses to distinct commensal-associated molecular patterns of probiotic strains
  • Role of gut microbiota in gastrointestinal and immunological diseases
  • Gut microbiota as an intervention target in metabolic function and obesity

Before submission authors should carefully read the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System on http://mts.hindawi.com/submit/journals/mi/mgmi/ according to the following schedule:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 765303
  • - Editorial

Mediators of Gut Mucosal Immunity and Inflammation

Ishak Ozel Tekin | H. Barbaros Oral | Ronit Shiri-Sverdlov
  • Special Issue
  • - Volume 2015
  • - Article ID 132458
  • - Research Article

Enhanced Levels of Chemokines and Their Receptors in the Colon of Microscopic Colitis Patients Indicate Mixed Immune Cell Recruitment

Sezin Günaltay | Ashok Kumar Kumawat | ... | Elisabeth Hultgren Hörnquist
  • Special Issue
  • - Volume 2015
  • - Article ID 176726
  • - Research Article

Innate Immunity Components and Cytokines in Gastric Mucosa in Children with Helicobacter pylori Infection

Jacek Michalkiewicz | Anna Helmin-Basa | ... | Katarzyna Dzierzanowska-Fangrat
  • Special Issue
  • - Volume 2015
  • - Article ID 263629
  • - Research Article

Claudin-4 Undergoes Age-Dependent Change in Cellular Localization on Pig Jejunal Villous Epithelial Cells, Independent of Bacterial Colonization

J. Alex Pasternak | Coral Kent-Dennis | ... | Heather L. Wilson
  • Special Issue
  • - Volume 2015
  • - Article ID 964131
  • - Review Article

Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update

Shane O’Sullivan | John F. Gilmer | Carlos Medina
  • Special Issue
  • - Volume 2015
  • - Article ID 304149
  • - Research Article

Enterococcus faecium NCIMB 10415 Modulates Epithelial Integrity, Heat Shock Protein, and Proinflammatory Cytokine Response in Intestinal Cells

Shanti Klingspor | Angelika Bondzio | ... | Ulrike Lodemann
  • Special Issue
  • - Volume 2015
  • - Article ID 219843
  • - Review Article

Transcriptional Regulators of Claudins in Epithelial Tight Junctions

Niamat Khan | Abdul R. Asif
  • Special Issue
  • - Volume 2015
  • - Article ID 579830
  • - Research Article

The Impact of ATRA on Shaping Human Myeloid Cell Responses to Epithelial Cell-Derived Stimuli and on T-Lymphocyte Polarization

Arunima Chatterjee | Péter Gogolak | ... | Éva Rajnavölgyi
  • Special Issue
  • - Volume 2015
  • - Article ID 427125
  • - Review Article

Pathophysiological Role of Extracellular Purinergic Mediators in the Control of Intestinal Inflammation

Yosuke Kurashima | Hiroshi Kiyono | Jun Kunisawa
  • Special Issue
  • - Volume 2015
  • - Article ID 624801
  • - Review Article

Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder

Mario Barbagallo | Francesco Marotta | Ligia J. Dominguez
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.